5 Conclusion
We confirmed that ALB, route of administration and concomitant
administration with GLU and PPIs are significantly associated with
voriconazole Cmin. EM and ALB significantly affect the
clearance of voriconazole. The
recommend dosing regimens based on CYP2C19 genotype and ALB levels
attained 67.22%-83.4% PTA, which could provide a reference for
voriconazole individualized treatment in children with hematological
malignancies.