ALB, albumin; CL, clearance; EM, Extensive metabolizer; EPS, residual variability; F, bioavailability; OFV, objective function value; RSE, relative prediction error; V, apparent volume of distribution; θ, pharmacokinetic parameter; IIV, interindividual variability.
Table4. The PTA of recommended dosing regimens for oral and intravenous administration based on group of ALB and CYP2C19 genotypes