variables Univariate analysis Univariate analysis Multiple linear regression Multiple linear regression
r P β P
AGE (years) 0.177 0.031*
WT (kg) 0.183 0.025*
Dose (mg/kg) 0.112 0.172
BMI (kg/m2) 0.05 0.548
BSA (m2) 0.181 0.028*
HGB (g/L) -0.29 <0.001*
PLT (109/L) -0.283 <0.001*
WBC (109/L) -0.184 0.025*
NEU (109/L) -0.129 0.117
TBIL (μmol/L) 0.311 <0.001*
GGT (U/L) -0.089 0.281
ALT (U/L) 0.051 0.54
AST (U/L) 0.078 0.343
ALP (U/L) -0.006 0.939
ALB(g/L) -0.418 <0.001* -0.19 0.000**
SCR (μmol/L) 0.066 0.423
CYSC (mg/L) 0.005 0.952
Ccr (mL/min) -0.02 0.565
Gender 0.646
male
famale
Route of administration 0.038*
intravenous 1.801 0.004**
oral
CYP2C19 genotype 0.038*
EM
IM, PM
Concomitant drugs
PPIs 0.004*
yes 1.985 0.004**
no
GLU 0.084*
yes -1.548 0.004**
no