2.4 Statistical analysis
The determinations of voriconazole Cmin were analyzed using multiple linear regression. The univariate analysis was used to initially screen variables and P <0.1 as the inclusion criterion. The Pearson or Spearman correlation analysis was used to analyze the correlation between continuous variables and voriconazole Cmin. Comparison of voriconazole Cminamong different group were performed by the independent sample t-tests or the Mann- Whitney U-test. The final results with P<0.05 were regarded as statistically significant. All statistical analyses performed using SPSS software (version 20.0, SPSS, Inc. Chicago, IL, USA).