3.2 Factors affecting voriconazole trough concentration
As shown in Table 2, the correlation analysis suggested that age, body weight, BSA, HGB, PLT, WBC, TBIL, ALB were associated with voriconazole Cmin (P<0.1). In addition, there is a significant difference of voriconazole Cmin in the groups of different CYP2C19 genotype, route of administration and concomitant administration with PPIs and GLU (P<0.1). The final multiple linear regression results revealed that route of administration, ALB and combined use of GLU and PPIs were the significant factors of voriconazole Cmin(P<0.05).