WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT?
• Invasive fungal infection dramatically affects the prognosis
of patients with hematologic malignancies and is one of the principal
causes of death in hematologic malignancies.
• Voriconazole has a complex pharmacokinetic profile and
exhibits different pharmacokinetic characteristics between adults and
children.
• There are still very limited data on the pharmacokinetics and
dosing optimization of voriconazole in children with hematological
malignancies.