WHAT THIS STUDY ADDS?
This study confirmed that ALB, route of administration and concomitant administration with glucocorticoid (GLU) and proton pump inhibitors (PPIs) are significantly associated with voriconazole trough concentration in children with hematological malignancies.
The population pharmacokinetics (PPK) analysis demonstrated that the extensive metabolizer, albumin significantly affects voriconazole clearance in children with malignant hematological disease.
The dosing regimen based on CYP2C19 genotype and albumin could provide a reference for individualized administration of voriconazole in clinical practice.