2.3 DNA sequencing and CYP2C19 genetic polymorphism
DNA was extracted with nucleic acid extraction and purification reagent from Baiao Technology Co. Ltd. (Shanghai, China). The CYP2C19 genotyping was performed by DNA Microarray with BR-526-24 -automatic hybridizer from Baiao Technology Co. Ltd. (Shanghai, China). The categories are as follows: (1) Extensive metabolizer (EM) (CYP2C19 *1/*1); (2) Intermediate metabolizer (IM) (CYP2C19 *1 /*2, CYP2C19 *1 /*3); (3) Poor metabolizer (PM) (CYP2C19*2 /*2, CYP2C19 *2 /*3, CYP2C19 *3/* 3)21.