2.6. Dosing Regimen Simulations
Based on the parameters and covariates obtained from the final model,
two CYP2C19 genotype groups: the extensive metabolizers (EM=1) and the
non-extensive metabolizers (EM=0) and three ALB groups :20.0
~ 35.0 g / L; 35.1 ~ 45.0 g / L; 45.1
~ 55.0 g / L were set respectively (ALB levels in this
study ranged from 22.7 to 56.6g/L; median: 34.2 g/L). The dosage
regimens of 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 mg/kg orally and
intravenously every 12 hours were simulated 1000 times for each
covariate group (the median and interquartile of body weight collected
were used as a fixed value and the dose should not exceed 200 mg/time).
The voriconazole Cmin ranged of 0.5 – 5 mg/L was
defined as target range20. A higher
probability of target attainment
(PTA) regimen with a lower probability of the Cminexceeding 5 mg/L was considered to be recommended.