ALB, albumin; CL, clearance; EM, Extensive metabolizer; EPS, residual
variability; F,
bioavailability;
OFV, objective function value; RSE, relative prediction error; V,
apparent volume of distribution; θ, pharmacokinetic parameter; IIV,
interindividual variability.
Table4. The PTA of recommended dosing regimens for oral and intravenous
administration based on group of ALB and CYP2C19 genotypes