2.3 DNA sequencing and CYP2C19 genetic polymorphism
DNA was extracted with nucleic acid extraction and purification reagent
from Baiao Technology Co. Ltd. (Shanghai, China). The CYP2C19 genotyping
was performed by DNA Microarray with BR-526-24 -automatic hybridizer
from Baiao Technology Co. Ltd. (Shanghai, China). The categories are as
follows: (1) Extensive metabolizer (EM) (CYP2C19 *1/*1); (2)
Intermediate metabolizer (IM) (CYP2C19 *1 /*2, CYP2C19 *1 /*3); (3) Poor
metabolizer (PM) (CYP2C19*2 /*2, CYP2C19 *2 /*3, CYP2C19 *3/*
3)21.