WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT?
Invasive fungal infection dramatically affects the prognosis of patients with hematologic malignancies and is one of the principal causes of death in hematologic malignancies.
Voriconazole has a complex pharmacokinetic profile and exhibits different pharmacokinetic characteristics between adults and children.
There are still very limited data on the pharmacokinetics and dosing optimization of voriconazole in children with hematological malignancies.