3.2 Factors affecting voriconazole trough concentration
As shown in Table 2, the correlation analysis suggested that age, body
weight, BSA, HGB, PLT, WBC, TBIL, ALB were associated with voriconazole
Cmin (P<0.1). In addition, there is a
significant difference of voriconazole Cmin in the
groups of different CYP2C19 genotype, route of administration and
concomitant administration with PPIs and GLU (P<0.1). The
final multiple linear regression results revealed that route of
administration, ALB and combined use of GLU and PPIs were the
significant factors of voriconazole Cmin(P<0.05).