5 Conclusion
We confirmed that ALB, route of administration and concomitant administration with GLU and PPIs are significantly associated with voriconazole Cmin. EM and ALB significantly affect the clearance of voriconazole. The recommend dosing regimens based on CYP2C19 genotype and ALB levels attained 67.22%-83.4% PTA, which could provide a reference for voriconazole individualized treatment in children with hematological malignancies.