Patient Age at diagnosis (years) Sex Pathology Family History Genetic Mutation(s) Outcome
1 15 Male Microinvasive, moderately differentiated adenocarcinoma arising in a tubulovillous adenoma No
APC
Alive, underwent laparoscopic partial colectomy with removal of sigmoid colon, undergoing endoscopic surveillance every 6 months
2 15 Male Moderately differentiated adenocarcinoma invading through the submucosa Yes
MSH3
Alive, underwent laparoscopic sub-total colectomy with ileo-sigmoid anastomosis, undergoing endoscopic surveillance annually
3 15 Male Poorly differentiated adenocarcinoma with medullary features and extensive necrosis No MLH1
c.156del (p.Glu53Argfs*4) APC
c.3329C>A (p.Ser1110*) SMAD4 c.947A>G (p.Asn316Ser)
Alive, underwent total colectomy with J-pouch creation and ileoanal anastomosis, undergoing endoscopic surveillance annually