FIGURE 4 Fingolimod treatment enhanced neurogenesis in the dentate gyrus of PCP-treated rats. (A) Confocal microscopic images depict BrdU-labelled newly generated cells (green), NeuN-labelled mature neuron (red), DAPI (blue), and DCX-labelled immature neuron (red) in the dentate gyrus. (B) Quantification of the BrdU-positive cell numbers in the dentate gyrus. (C) Quantitative analysis of the percentage of BrdU/NeuN double-stained cells (as indicated in arrows) in the dentate gyrus. (D) Quantitative analysis of DCX-positive cell numbers in the dentate gyrus. Scale bar = 100 μm. Data were showed as means ± SEM, n =7 per group, #P < .05, ##P < .01, versus control, **P < .01, ***P < .001 versus PCP. FTY, fingolimod; PCP, phencyclidine; SEM, standard error of the mean.