FIGURE 4 Fingolimod treatment enhanced neurogenesis in
the dentate gyrus of PCP-treated rats. (A) Confocal microscopic images
depict BrdU-labelled newly generated cells (green), NeuN-labelled mature
neuron (red), DAPI (blue), and DCX-labelled immature neuron (red) in the
dentate gyrus. (B) Quantification of the BrdU-positive cell numbers in
the dentate gyrus. (C) Quantitative analysis of the percentage of
BrdU/NeuN double-stained cells (as indicated in arrows) in the dentate
gyrus. (D) Quantitative analysis of DCX-positive cell numbers in the
dentate gyrus. Scale bar = 100 μm. Data were showed as means ± SEM, n =7
per group, #P < .05, ##P < .01, versus control,
**P < .01, ***P < .001 versus
PCP. FTY, fingolimod; PCP,
phencyclidine; SEM, standard error of the mean.