Conclusion
At 12 months the CORAL cohort has higher rates of egg sensitisation and
AD, but not egg allergy, when compared with a national historic dataset.
Antibiotic use and infant illness and hospitalisation were much lower in
this cohort and breastfeeding rates were dramatically higher than
pre-pandemic Irish figures. Microbiome analysis from 6-month and
12-month appointments are ongoing and may offer further explanation for
the increased sensitisation and AD seen in this cohort at 12 months in
the context of other favourable factors including increased
breastfeeding.
References
(1) Lawler M, Franklin R, McCallion N, Byrne AM, Fitzsimons J, Kinoshita
M, et al. The impact of COVID-19 lockdown on infants’ coronavirus
exposure and routine healthcare access in Ireland: The CORAL birth
cohort study at 6 months. Pediatr. Allergy Immunol. 2021;
10.1111/pai.13591 [doi].
(2) Hennessy Á, Hourihane JO, Malvisi L, Irvine AD, Kenny LC, Murray DM,
et al. Antenatal vitamin D exposure and childhood eczema, food allergy,
asthma and allergic rhinitis at 2 and 5 years of age in the atopic
disease-specific Cork BASELINE Birth Cohort Study. Allergy. 2018;
73 (11): 2182-2191. 10.1111/all.13590 [doi].
(3) Harris JM, Mills P, White C, Moffat S, Newman Taylor AJ, Cullinan P.
Recorded infections and antibiotics in early life: associations with
allergy in UK children and their parents. Thorax. 2007; 62 (7):
631-637. thx.2006.072124 [pii].
(4) Kadambari S, Goldacre R, Morris E, Goldacre MJ, Pollard AJ. Indirect
effects of the covid-19 pandemic on childhood infection in England:
population based observational study. BMJ. 2022; 376 e067519.
10.1136/bmj-2021-067519.
(5) Stam J, van Stuijvenberg M, Grüber C, Mosca F, Arslanoglu S, Chirico
G, et al. Antibiotic use in infants in the first year of life in five
European countries. Acta Paediatrica 2012; 101 (9): 929-934.
10.1111/j.1651-2227.2012.02728.x [doi].
(6) Lyons SA, Clausen M, Knulst AC, Ballmer-Weber BK, Fernandez-Rivas M,
Barreales L, et al. Prevalence of Food Sensitization and Food Allergy in
Children Across Europe. JACI; In practice. 2020; 8 (8):
2736-2746.e9. S2213-2198(20)30371-8 [pii].
(7) Healthcare Pricing Office. National Perinatal Reporting System
(NPRS).http://www.hpo.ie/latest_hipe_nprs_reports/NPRS_2015/Perinatal_Statistics_Report_2015.
pdf [Accessed 15/12/21].
(8) Layte, R. & McCrory, C. Maternal Health Behaviours and Child
Growth in Infancy:
Analyses of the Infant Cohort of the Growing Up in Ireland Study. 2014.
(9) Asher MI, Montefort S, Björkstén B, Lai CK, Strachan DP, Weiland SK,
et al. Worldwide time trends in the prevalence of symptoms of asthma,
allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One
and Three repeat multicountry cross-sectional surveys. Lancet.2006; 368 (9537): 733-743. S0140-6736(06)69283-0 [pii].
(10) Byrne A, Kelleher M, Hourihane JO. CORRESPONDENCE BSACI 2021
guideline for the management of egg allergy. Clin Exp allergy.2021; 10.1111/cea.14061 [doi].