Figure 3. Population predictions of right ventricular output vs
area under the dobutamine time-concentration curve (AUC) by GNAS
c.393C>T polymorphism, GA and SNAPPE-II score (1st
Quantile: 8.50 3rd Quantile:25.75) according to the final linear mixed
effects model.
AUTHORS’ CONTRIBUTIONS
MH conceived the study, participated in its design, collected data,
participated in data analysis, and drafted the manuscript. HS conducted
data analysis and revised the manuscript. TK and ÜM organised and
conducted genetic material analysis, participated in data analysis, and
revised the manuscript. M-LI conceived the study, collected the data,
and revised the manuscript. KK supported the work with LC-MS
quantification of dobutamine. TM conceived the study, participated in
its design, collected data, and drafted the manuscript. All authors read
and approved the final manuscript.
The data that support the findings of this study are available from the
corresponding author upon reasonable request.