Figure legends
Figure 1. Gene expression signatures between patients with AERD and
those with ATA. (A) Heatmap, (B) Scatter plot (C) Volcano plot for DEGs.
AERD, aspirin-exacerbated respiratory disease; ATA, aspirin tolerant
asthma; DEG, differentially expressed gene
Figure 2. Genome-wide methylation profiling of DMR. (A) Pheatmap of EPIC
(top 1,000 variable CpGs) according to aspirin intolerance. (B) Genomic
distribution of DNA methylation changes in AERD compared to ATA by
genomic features.
1st Exon: first exon region, 3’UTR: 3-prime
untranslated region, 5’UTR: 5-prime untranslated region, Body: gene
body, ExonBnd: exon boundaries, IGR: intergenic region, TSS200: region
from transcription start site (TSS) to −200 nt upstream of TSS, TSS1500:
−200 to −1500 nt upstream of TSS.
Figure 3. Heatmap of DCG pairs having an inverse correlation between
expression and methylation.
DCG, differentially correlated gene.
Figure 4. Gene connection (A) and signaling pathways with T helper cell
differentiation/activation (B) and Fc Epsilon RI signaling (C). The
bottom panel provides a legend of the IPA network.