Figure legends
Figure 1. Gene expression signatures between patients with AERD and those with ATA. (A) Heatmap, (B) Scatter plot (C) Volcano plot for DEGs.
AERD, aspirin-exacerbated respiratory disease; ATA, aspirin tolerant asthma; DEG, differentially expressed gene
Figure 2. Genome-wide methylation profiling of DMR. (A) Pheatmap of EPIC (top 1,000 variable CpGs) according to aspirin intolerance. (B) Genomic distribution of DNA methylation changes in AERD compared to ATA by genomic features.
1st Exon: first exon region, 3’UTR: 3-prime untranslated region, 5’UTR: 5-prime untranslated region, Body: gene body, ExonBnd: exon boundaries, IGR: intergenic region, TSS200: region from transcription start site (TSS) to −200 nt upstream of TSS, TSS1500: −200 to −1500 nt upstream of TSS.
Figure 3. Heatmap of DCG pairs having an inverse correlation between expression and methylation.
DCG, differentially correlated gene.
Figure 4. Gene connection (A) and signaling pathways with T helper cell differentiation/activation (B) and Fc Epsilon RI signaling (C). The bottom panel provides a legend of the IPA network.