Determination of DCGs (RNA and DMP)
DCGs are genes whose expression and DNA methylation patterns
significantly differ in patients with AERD compared to those with ATA.
With 1,736 DEGs (832 up-regulated, 904 down-regulated) and 1,401 DMPs
(897 genes), 83 pairs for DEG and its CpG which is located at the
promoter of the corresponding gene were found (Table S4). Finally, 19
pairs (19 DMPs and 18 DEGs) with negative correlation and atP <0.05 were selected (Figure 3, Table 2), and all
candidates were up-regulated and hypo-methylated in patients with AERD.