Simulation of dosing methods
Results of the simulated dosing methods based on median BSA, LBM, TBW and fixed dosing are presented in Table 3 and visualized in Figure 3. The optimal target AUC was calculated and resulted in an AUC of 3.13 mg.h/L. For evaluation of the simulated doses, MAPE for accuracy and ME for bias were calculated and showed in Table 3. The MAPE and ME of simulated dosing based on LBM, TBW or fixed dosing ME were not significant different compared to BSA. Except for the MAPE of dosing based on TBW, which was significant higher compared to BSA (p=0.001).