Toxicity correlations
The incidence of severe toxicity (i.e. ≥ grade 3) is shown in Table 4.
One patient experienced grade 3 mucositis, five patients experienced
grade 3 or 4 neutropenia and six patients had other forms of toxicity
(fatigue, febrile neutropenia, hyperglycaemia, infection, leucopenia,
and polyneuropathy). No significant relationships between any of the
pharmacokinetic parameters, any of the anthropometric/body composition
parameters, docetaxel dose, docetaxel/BSA, docetaxel/LBM or
docetaxel/TBW and overall toxicity were found.