INTRODUCTION
Lupus anticoagulant hypoprothrombinemia syndrome (LAHPS) is a rare
entity consisting of lupus anticoagulant (LA) positivity associated with
an acquired deficiency of coagulation factor II (FII). The origin of
this deficiency seems to be associated with acquired antibodies against
FII (anti-FII) 1. There is evidence of the presence of
non-neutralizing anti-FII antibodies in the plasma of these patients
with accelerated clearance of antigen-antibody complexes in the presence
of lupus anticoagulant2,3. It usually debuts in the
form of hemorrhagic events, despite LA positivity4.
Corticoesteroids and other immunosuppressive therapies have been used in
its treatment with variable but generally favorable
results5.