INTRODUCTION
Lupus anticoagulant hypoprothrombinemia syndrome (LAHPS) is a rare entity consisting of lupus anticoagulant (LA) positivity associated with an acquired deficiency of coagulation factor II (FII). The origin of this deficiency seems to be associated with acquired antibodies against FII (anti-FII) 1. There is evidence of the presence of non-neutralizing anti-FII antibodies in the plasma of these patients with accelerated clearance of antigen-antibody complexes in the presence of lupus anticoagulant2,3. It usually debuts in the form of hemorrhagic events, despite LA positivity4. Corticoesteroids and other immunosuppressive therapies have been used in its treatment with variable but generally favorable results5.