Introduction
Chronic rhinosinusitis (CRS) is a multifactorial heterogeneous disease,
although its pathogenesis and precise mechanism remains largely unclear.
Due to the poor understanding of the pathophysiology of CRS, it affects
the quality of life of patients and increases the cost burden as
compared to people without CRS. It is estimated to affect 8% of the
adult population in China. 1 According to the
EPOS2020, the current treatment for CRS includes medical therapy and
FESS with the final target to achieve cure or clinical control.2 Although, the disease state of
more
than 30% of patients with nasal polyps, remains uncontrolled despite
the current medical therapy (AMT) and FESS.3 DeConde
et al also reported the disease relapse in 40% of patients with nasal
polyps after 18 months. 4 The latest evidence has
further indicated that the underlying diversity of endotypes might be a
crucial reason for the unconformity in clinical phenotype and disease
prognosis.5 Therefore, it is essential to find
relevant clinical markers and to make a convenient model to predict the
poor disease control in CRS.
Emerging evidence has proven that eosinophil(EOS)inflammation is a
dominant factor associated with CRS recurrence and poor disease
control.6In
addition to the local eosinophils, peripheral blood eosinophils are also
associated with CRS and can be a reliable marker for predicting the
prognosis of CRS. Some studies have demonstrated the
peripheral
blood eosinophil as a marker for the EOS CRS. 6 In a
recent study, Guiherme et al, suggested that asthma was a dominant
factor for the recurrence of chronic rhinosinusitis. 7Nonetheless, some studies have reported that inhalant allergens may lead
to poor sinus CT and endoscopic scores. But several studies have found
no difference in allergic and nonatopic patients on the sinusitis
severity. 8 Thus, it is deemed necessary to evaluate
the role of allergy in nasal polyps’ disease control.
Undeniably studies on predictive factors of CRS treatment outcomes are
crucial and can help improvise personalized and integration management
of CRS in various hospitals. Therefore, this study aims to evaluate the
risk factors involved in the prognosis of CRS after 1 year of undergoing
endoscopic sinus surgery and combined the risk factors to establish a
convenient and accurate prediction model.