miRNA Known effect of miRNAs on various mammalian cells Predicted/validated glycosylation gene targets in miRWalk2.0 database and their possible impact on N-glycosylation in human cells miRNA engineering in this study Reference
miR-26b
Regulate cell proliferation and apoptosis
Gmds (8/12), Fpgt (6/12): regulate biosynthesis of GDP-fucose, and thus fucosylation
cgr-miR-26b OV
(43-46) & miRwalk 2.0
miR-30a
Regulate cell growth and productivity in CHO cells
B4galt1(8/12), SLC35A5(6/12), SLC35A3(6/12), SLC35C1(8/12).
cgr-miR-30a OV
(47, 48) & miRwalk 2.0
miR-30b
Regulate cell growth and productivity in CHO cells and changing apoptosis, O-glycosylation in human cancer cells
Fut8 (9/12): regulate fucosylation; Gale(7/12), B4galt1(8/12): regulate galactosylation; SLC35A2(7/12): regulate transport of UDP-galactose and thus galactosylation; SLC35A3(7/12): regulate transport of UDP-GlcNAc, and thus antennarity; SLC35A4(8/12), SLC35A5(6/12): ): regulate transport of both UDP-galactose and UDP-GlcNAc, and thus galactosylation and antennarity; SLC35C1(8/12): regulate transport of GDP-fucose, and thus fucosylation
cgr-miR-30b OV
(47-50) & miRwalk 2.0
miR-34a
Regulate cell proliferation and apoptosis
Mgat1 (7/12), Mgat4a (10/12), Mgat4b (6/12) , Mgat5b (8/12): regulate antennarity; Fut8 (10/12): regulate fucosylation; B4galt1(8/12): regulate galactosylation
cgr-miR-34a OV
(51-54) & miRwalk 2.0
miR-34c
Regulate cell proliferation apoptosis, and DNA replication
Mgat1 (8/12), Mgat4a (10/12): regulate antennarity; Fut8 (9/12): regulate fucosylation St3gal1(8/12): regulate sialylation
cgr-miR-34c KO
(55-60) & miRwalk 2.0
miR-122
Mgat4a (9/12): regulate antennarity Fut8 (8/12): regulate fucosylation
cgr-miR-122 OV
miRwalk 2.0
miR-128
Regulate cell proliferation, apoptosis, self-renewal, and differentiation
Mgat1 (7/12), Mgat4b (8/12): regulate antennarity
cgr-miR-128 KO
(61-65) & miRwalk 2.0
miR-181a
Regulate cell proliferation, apoptosis and differentiation
B4galt1(9/12): regulate galactosylation
cgr-miR-181a and b KO in combination (66-77) & miRwalk 2.0
miR-181b
St3gal1(8/12) : regulate sialylation B4galt1(9/12): regulate galactosylation
miR449a
Regulate cell proliferation and apoptosis
Mgat4a (10/12): regulate antennarity Fut8 (10/12): regulate fucosylation
putative-cgr-miR449a OV
(78-81) & miRwalk 2.0