Cases of CVE not associated with HGRT-related functional or
atypical mono/dual therapy
Twenty cases (39.2%) of CVE were not associated with HGRT-related
functional or atypical mono/dual therapy, so we sought to assess in
which features they differ from the other CVE. No statistical
differences in demographic, ART- and HIV-related characteristics were
found (n=20 vs 31; Suppl.Tab.4). Overall, these 20 participants started
the last ART regimen within a year in 70% of cases (versus 41.9%),
despite similar overall duration on any ART; they had higher proportion
of plasma suppression (75.0% versus 64.5%), lower CSF VL, and lower
CD4 count, suggesting that at least part of them could have been CSF
slow suppressor after viral failure requiring ART change. Thirteen
participants had no GRT testing in CSF at LP, and we cannot rule out
potential CSF RAMs explaining CVE. The remaining seven (13.7%) cases of
CVE without plasma and CSF RAMs affecting ART are described in
Suppl.Tab.5. Among these, three could be alternatively explained as CSF
blip or CSF slow suppression, and four cases (7.8% of the CVE cases)
remained etiologically elusive.