Statistical Analyses
CVE was compared to demographic, disease, ART, and HGRT variables. Data
were analyzed by nonparametric tests (Kruskal–Wallis, Mann–Whitney
test, Chi-square test for trend). Continuous and categorical variables
were reported as medians (interquartile range) and as absolute numbers
(proportion). The intra-subject median change in CPE score after
adjustment for HGRT was analyzed by paired Wilcoxon test reporting
Cohens D as effect size measure. Univariate and multivariable binary
logistic regressions were run to calculate unadjusted and adjusted odds
ratios (OR) of the outcome CVE after including variables with relevant
biological significance and those that showed univariate
p-value<0.05. Sensitivity analyses were conducted in
participants with plasma VL<50 cp/mL. Analyses were performed
using StataSE 17 (StataCorp LLC, USA).