1.3. Voltage-gated sodium channels
A consistent finding, both in the clinic and in the various mouse models discussed here, is a profound comorbidity between ASD and epilepsy \cite{RN35}. Thus, it is of no surprise that mutations in a third class of genes, voltage-gated sodium channel subunits, have been linked to both conditions. Mutations in the SCNA1 gene, encoding the Nav1.1 channel, result in Dravet syndrome, a neurodevelopmental disorder defined by treatment-resistant epilepsy, as well as ASD-like phenotypes \cite{RN36}. A second channel subunit implicated in both epilepsy and ASD is Nav1.2, encoded by the SCN2A gene. This gene has been highlighted as one of the most common monogenic sources of autism-causing mutations across multiple studies\cite{RN37}.