CGM glycaemic profiles between study participants who developed
GDM and those who did not
GV detected from the CGM of women in the first trimester of pregnancy
who developed GDM and those who did not were presented in Table 2. There
were no statistically significant differences in the GV parameters at
the time of CGM application at an average of 10 weeks of gestational
age. CGM application in the second trimester of pregnancy at an average
of 20 week of gestational age was associated with higher MAGE in the
group of women who developed GDM (3.18 + 0.68 vs 2.60 +0.53 mmol/L, p =0.02) compared to those who did not (Table 3).
Other parameters analyzed such as MBG, SDBG, %CV, J-Index, MAGE, %TIR,
%TAR and %TBR were not significantly different between the two groups.
It is notable that in both the first and second trimester of pregnancy,
there were consistent non-significant trends of higher MBG, SDBG and
%TAR, but lower %TIR in the group who developed GDM.
In sensitivity analyses (n=43), similar associations were observed with
only MAGE being higher in the GDM group compared to the non-GDM group
(3.18 + 0.68 vs 2.59 + 0.54, p =0.02). In addition,
there were non-significant trends observed with a higher %TAR
[(median 1.57, Interquartile range (IQR), 0.5-3.82) % vs 0.36 (IQR
0.04-1.37) %, p =0.09] and a lower %TBR [(9.7(IQR1.7- 11.2)
% vs 15.7 (IQR7.4-31.1) %, p=0.09] for participants who developed
GDM compared to those who did not (Supplementary Table S2).