Whole genome methylation microarray sequencing of CYP3A5*3/*3 genotype donor livers
Through principal component analysis, approximately 800,000 methylation sites were observed in the two-dimensional diagram after probe filtering and normalisation (Figure 1A ). Based on the methylationβ value between the 5 kb upstream and downstream transcription start sites (TSS), significant differences in methylation levels were observed between groups G1 and G2 (Figure 1B ). In addition, heat and scatter maps showed that there was a large number of methylation sites, with different levels of methylation, between groups G1 and G2 (Figure 1C and D ).