REFERENCES
1. Wu X, Yin C, Ma J, et al. Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo. Acta Pharm Sin B 2021;11:1885-1902.
2. Mallina H, Elumalai R, S FDP, et al. Computational validation of ABCB1 gene polymorphism and its effect on tacrolimus dose concentration/levels in renal transplant individuals of South India. Comput Biol Med 2021;139:104971.
3. Azam F, Khan M, Khaliq T, et al. Influence of ABCB1 gene polymorphism on concentration to dose ratio and adverse effects of tacrolimus in Pakistani liver transplant recipients. Pak J Med Sci 2021;37:689-694.
4. Sallustio BC, Noll BD, Hu R, et al. Tacrolimus dose, blood concentrations and acute nephrotoxicity, but not CYP3A5/ABCB1 genetics, are associated with allograft tacrolimus concentrations in renal transplant recipients. Br J Clin Pharmacol 2021;87:3901-3909.
5. Qin XL, Chen X, Zhong GP, et al. Effect of Tacrolimus on the pharmacokinetics of bioactive lignans of Wuzhi tablet (Schisandra sphenanthera extract) and the potential roles of CYP3A and P-gp. Phytomedicine 2014;21:766-72.
6. Li X, Zhao K, Ma N, et al. Association of ABCB1 promoter methylation with aspirin exposure, platelet function, and clinical outcomes in Chinese intracranial artery stenosis patients. Eur J Clin Pharmacol 2017;73:1261-1269.
7. Correa S, Binato R, Du Rocher B, et al. ABCB1 regulation through LRPPRC is influenced by the methylation status of the GC -100 box in its promoter. Epigenetics 2014;9:1172-83.
8. Chen Z, Cheng X, Zhang L, et al. The impact of IL-10 and CYP3A5 gene polymorphisms on dose-adjusted trough blood tacrolimus concentrations in early post-renal transplant recipients. Pharmacol Rep 2021;73:1418-1426.
9. Peng W, Lin Y, Zhang H, et al. Effect of ABCB1 3435C>T Genetic Polymorphism on Pharmacokinetic Variables of Tacrolimus in Adult Renal Transplant Recipients: A Systematic Review and Meta-analysis. Clin Ther 2020;42:2049-2065.
10. Kronfol MM, Jahr FM, Dozmorov MG, et al. DNA methylation and histone acetylation changes to cytochrome P450 2E1 regulation in normal aging and impact on rates of drug metabolism in the liver. Geroscience 2020;42:819-832.
11. Chequin A, Costa LE, de Campos FF, et al. Antitumoral activity of liraglutide, a new DNMT inhibitor in breast cancer cells in vitro and in vivo. Chem Biol Interact 2021;349:109641.
12. He H, Wang P, Li SG, et al. [Effects of pargyline on histone methylation in promoter and enhancer regions and transcription of CYP3A4/3A7]. Yao Xue Xue Bao 2017;52:91-8.
13. Lkhagvadorj K, Zeng Z, Meyer KF, et al. Postnatal Smoke Exposure Further Increases the Hepatic Nicotine Metabolism in Prenatally Smoke Exposed Male Offspring and Is Linked with Aberrant Cyp2a5 Methylation. Int J Mol Sci 2020;22.
14. Wang X, Wei L, Yang J, et al. DNA methylation determines the regulation of pregnane X receptor on CYP3A4 expression. Clin Exp Pharmacol Physiol 2021;48:250-259.
15. Onda K, Suzuki R, Tanaka S, et al. Decitabine, a DNA methyltransferase inhibitor, reduces P-glycoprotein mRNA and protein expressions and increases drug sensitivity in drug-resistant MOLT4 and Jurkat cell lines. Anticancer Res 2012;32:4439-44.
16. Li S, Zhang Y, Ho SH, et al. Combination of tumour-infarction therapy and chemotherapy via the co-delivery of doxorubicin and thrombin encapsulated in tumour-targeted nanoparticles. Nat Biomed Eng 2020;4:732-742.
17. Liu H, Yang ZK, Li Y, et al. ABCB1 variants confer susceptibility to primary open-angle glaucoma and predict individual differences to latanoprost treatment. Biomed Pharmacother 2016;80:115-120.
18. Jonaitis P, Jonaitis L, Kupcinskas J. Role of Genetic Polymorphisms of Cytochrome P450 2C19 in Pantoprazole Metabolism and Pantoprazole-based Helicobacter pylori Eradication Regimens. Curr Drug Metab 2020;21:830-837.
19. Habano W, Kawamura K, Iizuka N, et al. Analysis of DNA methylation landscape reveals the roles of DNA methylation in the regulation of drug metabolizing enzymes. Clin Epigenetics 2015;7:105.
20. Habano W, Gamo T, Sugai T, et al. CYP1B1, but not CYP1A1, is downregulated by promoter methylation in colorectal cancers. Int J Oncol 2009;34:1085-91.
21. Nakajima M, Iwanari M, Yokoi T. Effects of histone deacetylation and DNA methylation on the constitutive and TCDD-inducible expressions of the human CYP1 family in MCF-7 and HeLa cells. Toxicol Lett 2003;144:247-56.
22. Ye L, Xu Y, Wang L, et al. Downregulation of CYP2E1 is associated with poor prognosis and tumor progression of gliomas. Cancer Med 2021.
23. Luo R, Ge C, Xiao X, et al. Identification of genetic variations associated with drug resistance in non-small cell lung cancer patients undergoing systemic treatment. Brief Bioinform 2021;22.
24. Ohmura H, Ito M, Uchino K, et al. Methylation of drug resistance-related genes in chemotherapy-sensitive Epstein-Barr virus-associated gastric cancer. FEBS Open Bio 2020;10:147-157.
25. Xu L, Wang Y. Combined influence of ABCB1 genetic polymorphism and DNA methylation on aspirin resistance in Chinese ischemic stroke patients. Acta Neurol Belg 2021.
26. Wang J, Huang L, Gao P, et al. Diltiazem on tacrolimus exposure and dose sparing in Chinese pediatric primary nephrotic syndrome: impact of CYP3A4, CYP3A5, ABCB1, and SLCO1B3 polymorphisms. Eur J Clin Pharmacol 2021;77:71-77.
27. Vaclavikova R, Klajic J, Brynychova V, et al. Development of highresolution melting analysis for ABCB1 promoter methylation: Clinical consequences in breast and ovarian carcinoma. Oncol Rep 2019;42:763-774.
28. Wu P, Ni X, Wang M, et al. Polymorphisms in CYP3A5*3 and MDR1, and haplotype modulate response to plasma levels of tacrolimus in Chinese renal transplant patients. Ann Transplant 2011;16:54-60.
29. Yildirim E, Sahin G, Kaltus Z, et al. Effect of CYP3A5 and ABCB1 Gene Polymorphisms on Tacrolimus Blood Concentration in Renal Transplant Recipients. Clin Lab 2019;65.
30. Wu LX, Zhao HB, Wen CJ, et al. Combined Influence of Genetic Polymorphism and DNA Methylation on ABCB1 Expression and Function in Healthy Chinese Males. Eur J Drug Metab Pharmacokinet 2017;42:627-634.
31. Wu LX, Wen CJ, Li Y, et al. Interindividual epigenetic variation in ABCB1 promoter and its relationship with ABCB1 expression and function in healthy Chinese subjects. Br J Clin Pharmacol 2015;80:1109-21.
32. Yang J, Zhou JS, Zhao YX, et al. ABCB1 hypomethylation is associated with decreased antiplatelet effects of clopidogrel in Chinese ischemic stroke patients. Pharmazie 2015;70:97-102.