Whole genome methylation microarray sequencing of
CYP3A5*3/*3 genotype donor livers
Through principal component analysis, approximately 800,000 methylation
sites were observed in the two-dimensional diagram after probe filtering
and normalisation (Figure 1A ). Based on the methylationβ value between the 5 kb
upstream and downstream transcription start sites (TSS), significant
differences in methylation levels were observed between groups G1 and G2
(Figure 1B ). In addition, heat and scatter maps showed that
there was a large number of methylation sites, with different levels of
methylation, between groups G1 and G2 (Figure 1C and D ).