Results:
Out of 420 patients’, male (54.15%) and female (45.85%). Regarding age distribution mean age 34.1+-10.4 years. In (67%) of our studied group no cause was identified. It was found that (86.4%) of our patients had generalized Epilepsy while (13.6%) had focal Epilepsy. It appeared that (90%) of patients with generalized convulsion showed no abnormality on clinical examination. (50%) of patients with focal Epilepsy showed abnormal neurological manifestations, Almost (64.8%) showed abnormal EEG. The study showed that (90%) of patients with generalize epilepsy had a normal MRI of the brain. Those who had focal epilepsy, (50%) had abnormal MRI of the brain.Sodium valproate, carbamazipine, lamotrogine, levetiracetame, phenytoin, phenobarbitone were the drugs used to be taken by our patients.
Cosmetic side effects occurred in 20% of our studied group (84 patients).Hair loss was the most commonly reported cosmetic effect by female patients (8.2% p0.001 ) who were taking sodium valproate.(8.1 %,p0.001) of our patients had weight gain, weight gain was most frequently associated with valproic acid. Gingival hyperplasia, hirsutism and acne were the most commonly reported in patients taking phenytoin(2%,p0.oo1).One of our patient who used to take lamotrogine had loss of weight. One patient on phenobarbitone and one on carbamazipine had skin eruption. Cosmetic side effects leading to dosage change or discontinuation occurred most frequently with sodium valprote compared with all other AEDs (2.3% P 0.001). Neither of life score, nor adherence score were correlated with any of the cosmetic effects of AEDs (P>0.05).A significant positive correlations was found between the duration from the last attack and the quality of life score (P=0.03).