Specific Objectives:
To assess the impact of the cosmetic effects of AEDs on the quality of
life.
To assess the correlation between the cosmetic effects of AEDs and the
compliance with the medications.Methodology
Study design: this was prospective cross-sectional,
Descriptive study.
Study area: Subjects with epileptic seizures were randomly
recruited from Banat charity Neurological Referral Clinic.
- Location: Sudan, Omdurman, Omdurman south ( Coordinates: 15°39′N
32°29′E )
- Sudan is now the third largest country in Africa and also the third
largest country in the Arab world (estimated population is little over
30 million people)
- Omdurman is the largest city in Sudan and Khartoum State, lying on the
western banks of the River Nile, together With Khartoum and Khartoum
Bahri; it forms the cultural and industrial heart of the nation.
- Banat charity Neurological Referral Clinic is a charity clinic, in
which neurologists, psychiatrists, physicians, and medical registrars
tend to see patients every week at Friday, which is the weekend, and
many patients attend this clinic; they are from Khartoum state, but
also many of them from deferent states of Sudan. Also the clinic is
attended by medical students.
Study population: Patients who attend Banat charity
Neurological Referral Clinic.
- Inclusion Criteria: includes
1) Age ≥ 18 years;
2) History of ≥1 unprovoked seizure;
3) Nationality: Sudanese;
4) Patient with epilepsy who attend Banat charity neurological referral
clinic.- Exclusion Criteria: Patients that attend Banat charity
neurological referral clinic who are non-epileptic or male patients with
epilepsy. OR
1) Age < 18 years;
2) History of <1 unprovoked seizure;
3) Patients who is taking other drugs that can cause the same cosmetic
effects
Study duration: 6 month ( Mar - Aug 2014).
Sample technique: Simple random sampling /comprehensive
non-Probability sampling (Convenient sampling.).
Sample size is the total number during the study period
Data collection: Data collection and Tools: Interview with Pre-tested Questionnaires. For each subject, the
following data was collected: age, marital status, occupation,
residency, educational level, employment, age at seizure onset, seizure
type, etiology, and number of seizures before enrollment, history of
febrile seizures, and AEDs type and dosing, cosmetic effects, and
compliance with treatment.
- The Quality of Life in Epilepsy Inventory (QOLIE)-31.
- World Health Organization (26 items) QOL instrument (WHOQOL-brief).
- The Beck Depression Inventory (BDI) (Psychiatrist interview
(Interviewer are a Psychiatric registrars)?
- All interviewers are doctors graduated from faculty of medicine, or a
5th year medical student and above.
- Data analysis: All collected data were entered into the
computer using the statistical package program for social science
(SPSS) to analyze the data via simple descriptive statistics.
(Analyzer is specialized personnel in SPSS).
-
- Ethical concern: Written and verbal onsent was obtained from
all patients, and ethical approval was obtained from the State
Ministry of Health
- Limitations of the study:
-
Short duration of the study.
The drug serum levels will not be obtained