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Figure 1. Monkeypox virus transmission and clinical manifestations in humans. The monkeypox virus can be transmitted directly from monkeys to humans. It can also be transmitted to humans through monkey bites or scratches or eating bush meat of infected animals. After transmitting the virus, an infected person can have manifestations, such as skin rashes, myalgia, sepsis, fever, eye lesions, vomiting and diarrhea, headache, lymphadenopathy, or pneumonia.