Figure legends
Figure 1. Schematic overview of MAP3K7 showing the localization
of the different variants. Schematic overview of MAP3K7 showing
the Kinase and TAB1 binding domain at the N-terminal and the TAB2/3
binding domain at the C-terminal of MAP3K7 . In black the
CSCF-related MAP3K7 variants are indicated and in blue the
FMD2-related MAP3K7 variants. The underlined variants are the
novel variants identified in our cohort. MAP3K7P485Lis the most recurrent FMD2-causing variant.