Screening Accuracy
ROC analysis revealed excellent screening accuracy of the UCT in the
discrimination of poorly controlled CU at study entry (Figure 1A,
AUC=0.82 [95%CI: 0.71, 0.93]). For CU, the optimal cut-off value of
the UCT was determined to be ≤10 (sensitivity=95.5%,
specificity=63.3%). Similarly, screening accuracy of the UCT in CSU at
study entry also indicated excellent accuracy (Figure 1B, AUC=0.86
[95%CI: 0.74, 0.98]), also with an optimal cut-off of ≤10
(sensitivity=100.0%, specificity=65.0%). The UCT had acceptable
accuracy in the discrimination of poorly controlled CIndU (Figure 1C,
AUC=0.75 [95%CI: 0.50, 1.00]), with an optimal cut-off of ≤10
(sensitivity=85.7%, specificity=60.0%). Subgroup analysis of children
aged 4 to 16 years also revealed an acceptable screening accuracy of the
UCT (Figure 1D, AUC=0.79 [95%CI: 0.65, 0.93]), with an optimal
cut-off of ≤10 (sensitivity=92.9%, specificity=65.4%).