Resolution
Of the 52 participants, four (7.7%) participants were lost to
follow-up. From study entry, patients were followed for a median of 2.6
years (IQR: 0.9, 5.6). Disease resolution was recorded in 12 (25.0%) of
the remaining 48 participants over 248.0 patient-years (4.8 cases of
disease resolution per 100 patient-years). Among those whose disease
resolved, median age at resolution was 9.0 years (IQR: 8.0, 15.5) and
median disease duration was 3.5 years (IQR: 1.0, 7.0). Of those with
persistent coldU, median disease duration was 5.3 years (IQR: 2.0, 8.0).
Data on disease resolution was available in all 103 CSU patients, of
which 33 (32.0%) resolved over 290 patient-years (11.4 cases of
resolution per 100 patient-years). Of those experiencing CSU resolution,
median disease duration and age at disease resolution were 1.4 (IQR:
0.79, 2.1) and 9.0 (IQR: 4.9, 13.7) years, respectively. Median disease
duration was 2.3 years (IQR: 1.6, 4.0) in patients with persistent CSU.
When controlling for age at disease onset and sex, multivariate cox
regression analysis revealed that cases of coldU were significantly less
likely to experience disease resolution than cases of CSU (adjusted
hazard ratio: 0.43 [95%CI: 0.21, 0.89],
P<10-2, Figure 1).