Characteristics
Cold Urticaria Total No. (%) Chronic Spontaneous Urticaria Total No. (%)
P Value
Demographics Demographics Demographics Demographics
Patients 52 103 N/A
Female gender 27 (51.9) 50 (48.5) 0.82
Median age of symptom onset in years (IQR) 9.5 (4.8, 13.0) 5.0 (2.0, 10.0) N/A
Mean age of symptom onset (SD) 9.0 (4.4) 6.1 (4.5) <10-3
Diagnostic Testing Diagnostic Testing Diagnostic Testing Diagnostic Testing
Ice cube test 52 (100.0) N/A N/A
Positive ice cube test 47 (90.4) N/A N/A
Negative ice cube test/Atypical cold urticaria
5 (9.6)
N/A
N/A
Triggers Triggers Triggers Triggers
Swimming 28 (73.7), N=38 N/A N/A
Weather/Air 25 (65.8), N=38 N/A N/A
Food 7 (18.4), N=38 N/A N/A
Comorbidities Comorbidities Comorbidities Comorbidities
Other type of chronic urticaria 25 (48.1) N/A N/A
Chronic spontaneous urticaria 20 (42.3) N/A N/A
Cholinergic urticaria 3 (5.8) N/A N/A
Cholinergic and chronic spontaneous urticaria
2 (3.8)
N/A
N/A
Solar urticaria 0 (0.0) N/A N/A
Delayed pressure urticaria 0 (0.0) N/A N/A
Asthma 16 (30.8) 15 (14.6) 0.030
Atopic dermatitis 16 (30.8) 13 (12.6) 0.012
Allergic rhinitis 11 (21.2) 9 (8.7) 0.054
Food allergies 5 (9.6) 6 (5.8) 0.59
Autoimmune disease 2 (3.8) 6 (5.8) 0.89
Celiac disease 1 (1.9) 0 (0.0) 0.73
Type I diabetes mellitus 1 (1.9) 2 (1.9) 1.0
IgA nephropathy 0 (0.0) 1 (0.97) 1.0
Autoimmune thyroid disease 0 (0.0) 2 (1.9) 0.80
Lupus 0 (0.0) 1 (0.97) 1.0
Insect venom allergies 1 (1.9) 3 (2.9) 1.0
Autoinflammatory disease 0 (0.0) N/C N/A
Family History Family History Family History Family History
Atopy 8 (15.4) 22 (21.3) 0.50
Chronic urticaria 9 (17.3) 12 (11.7) 0.80
Cold urticaria 3 (5.8) N/C N/A
Symptoms Symptoms Symptoms Symptoms
Angioedema 15 (28.8) 24 (23.3) 0.58
Cold-induced anaphylaxis 9 (17.3) N/A N/A
Laboratory Values Laboratory Values Laboratory Values Laboratory Values
Tryptase (>13.5ug/mL) 1 (2.3), N=43 0 (0.0), N=96 0.68
IgE ( >240IU/mL) 25 (64.1), N=39 34 (37.8), N=90 0.010
CRP (>5mg/L) 2 (4.8), N=42 8 (8.7), N=92 0.65
Blood eosinophils (>0.60 x 109/L) 7 (15.6), N=45 6 (6.0), N=100 0.12