Figure 1 Pharmacological evidence of functional involvement of
T-type channels in the development and maintenance of inflammation and
related pain
The effect of acute TTA-A2 (1 mg/kg, per os ) or vehicle (VEH)
treatment was assessed in mice 4h after an intraplantar injection of
carrageenan (right ) or 7 days after an intra-articular
administration of Complete Freund’s Adjuvant (CFA, middle ). In
the CFA model, the effect of repeated (3 times a day from day 7 to day
14) administrations of TTA-A2 (1 mg/kg, per os ) or VEH was also
investigated (left ). In all conditions, mechanical allodynia
(A ), mechanical hyperalgesia (B ) and paw edema
(C ) were assessed. Statistical differences were assessed by
two-way ANOVA (Time, Treatments) followed by Bonferroni post-hoc test
[significant differences between VEH and TTA-A2 group are indicated by
asterisks (*p < 0.05; **p < 0.01;
***p < 0.001)]. Data represent mean ± SEM.