Figure 3 Contribution of peripheral-located
Cav3.2 channels in inflammatory pain
Mechanical allodynia (left ) and mechanical hyperalgesia
(right ) were assessed in
Cav3.2Nav1.8 cKO mice and their
control littermates (Cav3.2GFP-floxKI) receiving either an intraplantar injection of carrageenan
(A ) or intraarticular CFA (B ). Mice were submitted to
the von Frey test to assess mechanical allodynia (left ) and
hyperalgesia (right ). Statistical differences were assessed by
two-way ANOVA (Time, Genotype or Treatments) followed by Bonferroni
post-hoc test [significant differences between
Cav3.2Nav1.8 cKO and
Cav3.2GFP-flox KI group are indicated
by asterisks (*p < 0.05; **p < 0.01;
***p < 0.001)]. Data represent mean ± SEM.