Variable Subclavian (n=290) Transapical (n=1216) P value
Age (y) 80.5 (± 6.81) 80.2 (± 7.92) 0.54
Male 202 (70 %) 709 (58 %) 0.03a
Female 88 (30 %) 507 (42 %) 0.04 a
NYHA III-IV 226 (78 %) 1216 (100 %) 0.058
CCS 3-4 41 (14 %) 163 (13 %) 0.62
Logistic Euro-SCORE 22 (±1.6) 20 (±2.3) 0.06
Frailty score (CSHA) 6 -7 19 (7 %) 85 (7%) 0.98
Katz index (1-2) 2 (0.7 %) 12 (1 %) 0.89
Poor mobility 29 (10 %) 127 (10 %) 0.98
Critical preoperative status 4 (1 %) 13 (1 %) 0.99
Height (m) 1.66 (± 0.10) 1.63 (± 0.10) 0.79
Weight (kg) 74.35 (±17.45) 74.31 (±15.42) 0.75
Creatinine (mmol/l) 115 (± 60.80) 120 (±23.01) 0.42
Pre op dialysis 1 (0.34 %) 4 (0.32 %) 0.41
Diabetes 79 (27 %) 328 (27 %) 0.92
Insulin
13 (16 %)
195 (16 %)
0.92
Oral drugs
45 (57 %)
681 (56 %)
0.89
Diet treatment
21 (27 %)
340 (28 %)
0.90
Non-diabetic
211 (73 %)
888 (73 %)
0.94
Current smoker 24 (8 %) 97 (8 %) 0.97
Ex-smoker 177 (61 %) 705 (58 %) 0.89
Never smoker 89 (31 %) 413 (34 %) 0.88
COPD/Pulmonary disease 89 (31 %) 378 (31 %) 0.98
Severe liver disease 2 (0.7 %) 12 (1 %) 0.87
Atrial fibrillation 74 (26 %) 255 (21 %) 0.78
Neurological disease 65 (22 %) 231 (19 %) 0.85
Extracardiac arteriopathy 152 (52 %) 632 (52 %) 0.98
Ascending aorta calcification 65 (22 %) 280 (23 %) 0.84
Previous cardiac surgery 86 (30%) 556 (46%) 0.15
Previous MI 75 (26 %) 328 (27 %) 0.81
Previous PCI 75 (26 %) 194 (16 %) 0.76
Coronary artery disease 141 (49 %) 559 (46 %) 0.68
LMS disease > 50 % 19 (6 %) 61 (5 %) 0.55
LVEF > 50 % 155 (54 %) 705 (58 %) 0.61
LVEF 30-49 % 107 (37 %) 389 (32 %) 0.54
LVEF < 30% 26 (9 %) 122 (10 %) 0.46
Aortic peak gradient (mmHg) 78.03 (± 28.99) 76.03 (± 29.19) 0.43
Aortic mean gradient (mmHg) 48.06 (± 15.37) 47.06 (± 19.37) 0.64
Aortic valve area (cm2) 1.07 (± 4.72) 1.02 (± 4.74) 0.45
Aortic annulus (mm) 23.76 (± 2.82) 23.71 (± 2.12) 0.34
MVR (moderate-severe) 20 (7 %) 97 (8 %) 0.09