Ocean & seas: Promising biomedical resources for
infection-related mNCDs
Generally speaking, chronic or acute infection highly links with
cardiovascular disease (hypertension, myocardial infarction, arrhythmia,
heart failure, and stroke), diabetes, cancer, respiratory and renal
diseases as well as the related CDC strips or Re-CDC strips [36,
37]. Some MNPs have numerous health benefits, such as antioxidant,
anti-infection, anti-inflammatory, anticoagulant, anti-diabetic effects,
and cancer treatment [38, 39]. Thus, marine drugs are not just
suitable for infectious diseases, but also for prevention and treatment
major noncommunicable diseases (mNCDs).
A study found that mineral-balanced deep sea water [magnesium
(Mg):calcium (Ca)=3:1] (MB-DSW) has anti-atopic dermatitis activity
due to regression of inflammatory chemokines [40]. Other studies
found that MB-DSW has anti-diabetic and anti-obesity action [41] due
to the stimulatory effect on mitochondrial biogenesis and function and
enriched with Mg and Ca, and the effects on cholesterol metabolism
[42] due to prevention of the high glucose- or FFA/glucose-induced
increase of cellular cholesterol levels (is its potential just like
statin drugs?), and the role of the prevention of ultraviolet
light-induced skin cancer development [43] due to enhancing skin
cell clearance through the activation of autophagic cell death.
In addition, recombinant photoproteins from different marine organisms
as a promising analytical tool have a big role in biomedical research
fields [44], such as the measurement of Ca2+ in
different intracellular compartments of animal cells, as labels in the
design and development of binding assays as well as the emerging use of
bioluminescence.