Enrolment
A total of 180 patients were diagnosed from chronic or episodic migraine by one of the headache specialists at Alicante General University Hospital between November 1, 2019, and January 31, 2021. Eligibility and enrolment are depicted in Figure 1 . Twenty-six patients were determined to be ineligible due to loss of follow-up (14,69%), seven for concomitant well-defined psychiatric disorders (3,95%), three for receiving the treatment outside our hospital (1,69%) and two for not collecting the medication when scheduled (1,13%).