Disclosure of Interests
All authors have completed the Unified Competing Interest form  (available on request from the corresponding author) and declare financial support from the Red Nose Foundation, the National Health and Medical Research Council (NHMRC) Centre for Research Excellence(CRE) and a NHMRC programme grant (APP1113902); no financial relationships with any organisations that might have an interest in the submitted work in the previous three years, no other relationships or activities that could appear to have influenced the submitted work.