Search strategy and study selection:
PubMed (Medline) and Cochrane were searched in depth from the time of inception of the study to August 1st, 2022. Literature and preprints were identified through searches of ClinicalTrials.gov, Google Scholar, and Medrxiv. A search strategy was created using keywords and Medical Subject Headings (MESH terms) which included [Finerenone OR Non-steroidal mineralocorticoid receptor antagonist OR Non-steroidal MRA] AND [ Cardiac outcomes OR Cardio renal outcomes] AND [Type 2 diabetes OR Diabetes Mellitus]. The search methodology is described in full in the Supplementary Table S1. The search results were returned without any sort of restriction or filtering. Text written in a language other than English was translated using Google’s built-in translate service. To find applicable studies, a manual search of reviews was carried out. Titles, full texts, and abstracts of studies were screened by two reviewers (MK and SK) independently. To further eliminate duplicates, we imported the relevant studies into Endnote X9 (Clarivate Analytics, US).