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\begin{document}

\title{The burden of seasonal influenza in Italy: a systematic review of
influenza-related complications, hospitalizations, and mortality}



\author[1]{Irene Giacchetta}%
\author[1]{Chiara Primieri}%
\author[1]{Riccardo Cavalieri}%
\author[2]{Alexander Domnich}%
\author[1]{Chiara de Waure}%
\affil[1]{University of Perugia}%
\affil[2]{IRCCS for Oncology and Neurosciences}%


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  \date{June 17, 2024}


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\begin{abstract}
Background: reliable country-specific data on influenza burden play a
crucial role in informing prevention and control measures. Our purpose
was to provide a comprehensive summary of the available evidence on the
burden of seasonal influenza in Italy. Methods: we performed a
sys-tematic literature review of articles published until 31 July 2020.
PubMed, Embase and Web of Science were searched using terms related to
burden, influenza, and Italian population. We in-cluded studies
investigating seasonal influenza-related complications, hospitalizations
and/or mortality. Results: sixteen studies were included: eight (50\%)
analyzed influenza-related compli-cations, eight (50\%)
hospitalizations, while seven (43.8\%) influenza-related deaths. Only
three studies (19.7\%) concerned pediatric age. The synthesis of results
showed that patients with chron-ic conditions have an increased risk for
complications up to almost three times as compared to healthy people.
Hospitalizations due to influenza can occur in as much as 5\% of
infected people depending on the study setting. Excess deaths rates were
over six-fold higher in the elderly as compared to the rest of
population. Conclusions: although there are still gaps in existing data,
there is evidence of the significant burden that influenza places each
year especially on high-risk groups. These data should be used to inform
public health decision-making.%
\end{abstract}%



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