References
1. March of Dimes, PMNCH, Save the Children, WHO. Born Too Soon: The Global Action Report on Preterm Birth. Geneva; 2012.
2. Collins J. Global epidemiology of multiple birth. Reprod Biomed Online. 2007;15 Suppl 3:45–52.
3. Goldenberg RL, Iams JD, Miodovnik M, Van Dorsten JP, Thurnau G, Bottoms S, et al. The preterm prediction study: risk factors in twin gestations. National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Am J Obstet Gynecol. 1996 Oct;175(4 Pt 1):1047–53.
4. Souka AP, Heath V, Flint S, Sevastopoulou I, Nicolaides KH. Cervical length at 23 weeks in twins in predicting spontaneous preterm delivery. Obstet Gynecol. 1999 Sep;94(3):450-4. doi: 10.1016/s0029-7844(99)00277-x. PMID: 10472876.
5. EPPPIC Group. Evaluating Progestogens for Preventing Preterm birth International Collaborative (EPPPIC): meta-analysis of individual participant data from randomized controlled trials. Lancet 2021 Mar;397(10280):1183–94. doi: 10.1016/S0140-6736(21)00217-8. Erratum in: Lancet. 2021 Apr 17;397(10283):1446. PMID: 33773630.
6. D’Antonio F, Berghella V, Di Mascio D, Saccone G, Sileo F, Flacco ME, et al. Role of progesterone, cerclage and pessary in preventing preterm birth in twin pregnancies: A systematic review and network meta-analysis. Eur J Obstet Gynecol Reprod Biol. 2021 Jun;261:166–77
7. El-Refaie W, Abdelhafez MS, Badawy A. Retraction Note: Vaginal progesterone for prevention of preterm labor in asymptomatic twin pregnancies with sonographic short cervix: a randomized clinical trial of efficacy and safety. Arch Gynecol Obstet. 2021 Oct;304(4):1113.
8. Pacagnella RC, Silva TV, Cecatti JG, Passini R Jr, Fanton TF, Borovac-Pinheiro A, et al. Pessary Plus Progesterone to Prevent Preterm Birth in Women With Short Cervixes: A Randomized Controlled Trial. Obstet Gynecol. 2022 Jan 1;139(1):41-51. doi: 10.1097/AOG.0000000000004634. PMID: 34856583.
9. Groussolles M, Winer N, Sentilhes L, Biquart F, Massoud M, Vivanti AJ,
et al. Arabin pessary to prevent adverse perinatal outcomes in twin pregnancies with a short cervix: a multicenter randomized controlled trial (PESSARONE). Am J Obstet Gynecol. 2022 Aug;227(2):271.e1-271.e13. doi: 10.1016/j.ajog.2022.01.038. Epub 2022 Feb 3. PMID: 35123930.
10. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021 Mar 29;372:n71. doi: 10.1136/bmj.n71. PMID: 33782057; PMCID: PMC8005924.
11. Liem S, Schuit E, Hegeman M, Bais J, de Boer K, Bloemenkamp K, et al. Cervical pessaries for prevention of preterm birth in women with a multiple pregnancy (ProTWIN): a multicentre, open-label randomised controlled trial. Lancet. 2013 Oct 19;382(9901):1341-9. doi: 10.1016/S0140-6736(13)61408-7. Epub 2013 Aug 5. PMID: 23924878.
12. Sterne JAC, Savović J, Page MJ, Elbers RG, Blencowe NS, Boutron I, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ 2019; 366: l4898
13. Ben W. Mol, Shimona Lai, Ayesha Rahim, Wentao Li. A Screening Checklist to Assess Data Integrity and Fabrication in Randomized Clinical Trials. Ninth International Congress on Peer Review and Scientific Publication, September 8-10, 2022.
14. Nikolakopoulou A, Higgins JPT, Papakonstantinou T, Chaimani A, Del Giovane C, Egger M, et al. CINeMA: An approach for assessing confidence in the results of a network meta-analysis. PLoS Med. 2020 Apr 3;17(4):e1003082. doi: 10.1371/journal.pmed.1003082. PMID: 32243458; PMCID: PMC7122720.
15. Rouse DJ, Caritis SN, Peaceman AM, Sciscione A, Thom EA, Spong CY, et al. A trial of 17 alpha-hydroxyprogesterone caproate to prevent prematurity in twins. N Engl J Med. 2007 Aug 2;357(5):454-61. doi: 10.1056/NEJMoa070641. PMID: 17671253.
16. Awwad J, Usta IM, Ghazeeri G, Yacoub N, Succar J, Hayek S, et al. A randomised controlled double-blind clinical trial of 17-hydroxyprogesterone caproate for the prevention of preterm birth in twin gestation (PROGESTWIN): evidence for reduced neonatal morbidity. BJOG. 2015 Jan;122(1):71-9. doi: 10.1111/1471-0528.13031. Epub 2014 Aug 27. PMID: 25163819.
17. Crowther CA, Ashwood P, McPhee AJ, Flenady V, Tran T, Dodd JM, et al. Vaginal progesterone pessaries for pregnant women with a previous preterm birth to prevent neonatal respiratory distress syndrome (the PROGRESS Study): A multicentre, randomised, placebo-controlled trial. PLoS Med. 2017 Sep 26;14(9):e1002390. doi: 10.1371/journal.pmed.1002390. PMID: 28949973; PMCID: PMC5614421.
18. Aboulghar MM, El-Faissal Y, Kamel A, Mansour R, Serour G, Aboulghar M, et al. The effect of early administration of rectal progesterone in IVF/ICSI twin pregnancies on the preterm birth rate: a randomized trial. BMC Pregnancy Childbirth. 2020 Jun 9;20(1):351. doi: 10.1186/s12884-020-03033-4. PMID: 32517660; PMCID: PMC7285559.
19. Norman JE, Mackenzie F, Owen P, Mactier H, Hanretty K, Cooper S, et al. Progesterone for the prevention of preterm birth in twin pregnancy (STOPPIT): a randomised, double-blind, placebo-controlled study and meta-analysis. Lancet. 2009 Jun 13;373(9680):2034-40. doi: 10.1016/S0140-6736(09)60947-8. PMID: 19523680.
20. Combs CA, Garite T, Maurel K, Das A, Porto M; Obstetrix Collaborative Research Network. Failure of 17-hydroxyprogesterone to reduce neonatal morbidity or prolong triplet pregnancy: a double-blind, randomized clinical trial. Am J Obstet Gynecol. 2010 Sep;203(3):248.e1-9. doi: 10.1016/j.ajog.2010.06.016. Erratum in: Am J Obstet Gynecol. 2011 Feb;204(2):166. PMID: 20816146.
21. Hajizadeh N, Saharkhiz N, Hosseini S, Arabzadeh B. Comparison of cerclage and pessary in prevention of preterm birth in twin pregnancies. Med J Islam Repub Iran. 2020 Jul 6;34:74. doi: 10.34171/mjiri.34.74. PMID: 33306065; PMCID: PMC7711049.
22. Klein K, Rode L, Nicolaides KH, Krampl-Bettelheim E, Tabor A; PREDICT Group. Vaginal micronized progesterone and risk of preterm delivery in high-risk twin pregnancies: secondary analysis of a placebo-controlled randomized trial and meta-analysis. Ultrasound Obstet Gynecol. 2011 Sep;38(3):281-7. doi: 10.1002/uog.9092. PMID: 21739499.
23. Caritis SN, Simhan HN, Zhao Y, Rouse DJ, Peaceman AM, Sciscione A, et al. Relationship between 17-hydroxyprogesterone caproate concentrations and gestational age at delivery in twin gestation. Am J Obstet Gynecol. 2012 Nov;207(5):396.e1-8. doi: 10.1016/j.ajog.2012.08.001. Epub 2012 Aug 6. PMID: 22959763; PMCID: PMC3484214.
24. Merced C, Goya M, Pratcorona L, Rodó C, Llurba E, Higueras T, et al. Cervical pessary for preventing preterm birth in twin pregnancies with maternal short cervix after an episode of threatened preterm labor: randomised controlled trial. Am J Obstet Gynecol. 2019 Jul;221(1):55.e1-55.e14. doi: 10.1016/j.ajog.2019.02.035. Epub 2019 Feb 28. Erratum in: Am J Obstet Gynecol. 2021 May;224(5):532. PMID: 30826339.
25. El-Refaie W, Abdelhafez MS, Badawy A. Vaginal progesterone for prevention of preterm labor in asymptomatic twin pregnancies with sonographic short cervix: a randomized clinical trial of efficacy and safety. Arch Gynecol Obstet. 2016 Jan;293(1):61-67. doi: 10.1007/s00404-015-3767-1. Epub 2015 Jun 5. Retraction in: Arch Gynecol Obstet. 2021 Oct;304(4):1113. PMID: 26044148.
26. Cetingoz E, Cam C, Sakallı M, Karateke A, Celik C, Sancak A. Progesterone effects on preterm birth in high-risk pregnancies: a randomized placebo-controlled trial. Arch Gynecol Obstet. 2011 Mar;283(3):423-9. doi: 10.1007/s00404-009-1351-2. Epub 2010 Jan 22. PMID: 20091317.
27. Abdel Wahab AS, Abdelmonaem MI, Mahmoud WM, Mansour AE. A randomized controlled trial of two-doses of vaginal progesterone 400 vs. 200 mg for prevention of preterm labor in twin gestations. J Perinat Med. 2021 Sep 14. doi: 10.1515/jpm-2021-0131. Epub ahead of print. PMID: 34523303.
28. Rust OA, Atlas RO, Jones KJ, Benham BN, Balducci J. A randomized trial of cerclage versus no cerclage among patients with ultrasonographically detected second-trimester preterm dilatation of the internal os. Am J Obstet Gynecol. 2000 Oct;183(4):830-5. doi: 10.1067/mob.2000.109040. PMID: 11035321.
29. Berghella V, Odibo AO, Tolosa JE. Cerclage for prevention of preterm birth in women with a short cervix found on transvaginal ultrasound examination: a randomized trial. Am J Obstet Gynecol. 2004 Oct;191(4):1311-7. doi: 10.1016/j.ajog.2004.06.054. PMID: 15507959.
30. Fonseca EB, Celik E, Parra M, Singh M, Nicolaides KH; Fetal Medicine Foundation Second Trimester Screening Group. Progesterone and the risk of preterm birth among women with a short cervix. N Engl J Med. 2007 Aug 2;357(5):462-9. doi: 10.1056/NEJMoa067815. PMID: 17671254.
31. Rode L, Klein K, Nicolaides KH, Krampl-Bettelheim E, Tabor A; PREDICT Group. Prevention of preterm delivery in twin gestations (PREDICT): a multicenter, randomized, placebo-controlled trial on the effect of vaginal micronized progesterone. Ultrasound Obstet Gynecol. 2011 Sep;38(3):272-80. doi: 10.1002/uog.9093. PMID: 21739497.
32. Aboulghar MM, Aboulghar MA, Amin YM, Al-Inany HG, Mansour RT, Serour GI. The use of vaginal natural progesterone for prevention of preterm birth in IVF/ICSI pregnancies. Reprod Biomed Online. 2012 Aug;25(2):133-8. doi: 10.1016/j.rbmo.2012.03.013. Epub 2012 Apr 3. PMID: 22695310.
33. Wood S, Ross S, Tang S, Miller L, Sauve R, Brant R. Vaginal progesterone to prevent preterm birth in multiple pregnancy: a randomized controlled trial. J Perinat Med. 2012 Nov;40(6):593-9. doi: 10.1515/jpm-2012-0057. PMID: 23093256.
34. Serra V, Perales A, Meseguer J, Parrilla JJ, Lara C, Bellver J, et al. Increased doses of vaginal progesterone for the prevention of preterm birth in twin pregnancies: a randomised controlled double-blind multicentre trial. BJOG. 2013 Jan;120(1):50-7. doi: 10.1111/j.1471-0528.2012.03448.x. Epub 2012 Aug 13. PMID: 22882759.
35. Brizot ML, Hernandez W, Liao AW, Bittar RE, Francisco RPV, Krebs VLJ, et al. Vaginal progesterone for the prevention of preterm birth in twin gestations: a randomized placebo-controlled double-blind study. Am J Obstet Gynecol. 2015 Jul;213(1):82.e1-82.e9. doi: 10.1016/j.ajog.2015.02.021. Epub 2015 Feb 27. PMID: 25731690.
36. Rehal A, Benkő Z, De Paco Matallana C, Syngelaki A, Janga D, Cicero S, et al. Early vaginal progesterone versus placebo in twin pregnancies for the prevention of spontaneous preterm birth: a randomized, double-blind trial. Am J Obstet Gynecol. 2021 Jan;224(1):86.e1-86.e19. doi: 10.1016/j.ajog.2020.06.050. Epub 2020 Jun 26. PMID: 32598909.
37. Briery CM, Veillon EW, Klauser CK, Martin RW, Magann EF, Chauhan SP, et al. Women with preterm premature rupture of the membranes do not benefit from weekly progesterone. Am J Obstet Gynecol. 2011 Jan;204(1):54.e1-5. doi: 10.1016/j.ajog.2010.08.022. PMID: 20869038.
38. Durnwald CP, Momirova V, Rouse DJ, Caritis SN, Peaceman AM, Sciscione A. Se, et al. Second trimester cervical length and risk of preterm birth in women with twin gestations treated with 17-α hydroxyprogesterone caproate. J Matern Fetal Neonatal Med. 2010 Dec;23(12):1360-4. doi: 10.3109/14767051003702786. Epub 2010 May 4. PMID: 20441408; PMCID: PMC2999406.
39. Combs CA, Garite T, Maurel K, Das A, Porto M; Obstetrix Collaborative Research Network. 17-hydroxyprogesterone caproate for twin pregnancy: a double-blind, randomized clinical trial. Am J Obstet Gynecol. 2011 Mar;204(3):221.e1-8. doi: 10.1016/j.ajog.2010.12.042. PMID: 21376161.
40. Lim AC, Schuit E, Bloemenkamp K, Bernardus RE, Duvekot JJ, Erwich JJHM, et al. 17α-hydroxyprogesterone caproate for the prevention of adverse neonatal outcome in multiple pregnancies: a randomized controlled trial. Obstet Gynecol. 2011 Sep;118(3):513-520. doi: 10.1097/AOG.0b013e31822ad6aa. PMID: 21860279.
41. Senat MV, Porcher R, Winer N, Vayssière C, Deruelle P, Capelle M, et al. Prevention of preterm delivery by 17 alpha-hydroxyprogesterone caproate in asymptomatic twin pregnancies with a short cervix: a randomized controlled trial. Am J Obstet Gynecol. 2013 Mar;208(3):194.e1-8. doi: 10.1016/j.ajog.2013.01.032. PMID: 23433324.
42. Liem S, Schuit E, Hegeman M, Bais J, de Boer K, Bloemenkamp K, et al. Cervical pessaries for prevention of preterm birth in women with a multiple pregnancy (ProTWIN): a multicentre, open-label randomised controlled trial. Lancet. 2013 Oct 19;382(9901):1341-9. doi: 10.1016/S0140-6736(13)61408-7. Epub 2013 Aug 5. PMID: 23924878.
43. Nicolaides KH, Syngelaki A, Poon LC, de Paco Matallana C, Plasencia W, Molina FS, et al. Cervical pessary placement for prevention of preterm birth in unselected twin pregnancies: a randomized controlled trial. Am J Obstet Gynecol. 2016 Jan;214(1):3.e1-9. doi: 10.1016/j.ajog.2015.08.051. Epub 2015 Aug 28. PMID: 26321037.
44. Goya M, de la Calle M, Pratcorona L, Merced C, Rodó C, Muñoz B, et al; PECEP-Twins Trial Group. Cervical pessary to prevent preterm birth in women with twin gestation and sonographic short cervix: a multicenter randomized controlled trial (PECEP-Twins). Am J Obstet Gynecol. 2016 Feb;214(2):145-152. doi: 10.1016/j.ajog.2015.11.012. Epub 2015 Nov 25. PMID: 26627728.
45. Berghella V, Dugoff L, Ludmir J. Prevention of preterm birth with pessary in twins (PoPPT): a randomized controlled trial. Ultrasound Obstet Gynecol. 2017 May;49(5):567-572. doi: 10.1002/uog.17430. PMID: 28170117.
46. Norman JE, Norrie J, MacLennan G, Cooper D, Whyte S, Chowdhry S, et al. Evaluation of the Arabin cervical pessary for prevention of preterm birth in women with a twin pregnancy and short cervix (STOPPIT-2): An open-label randomised trial and updated meta-analysis. PLoS Med. 2021 Mar 29;18(3):e1003506. doi: 10.1371/journal.pmed.1003506. PMID: 33780463; PMCID: PMC8041194.
47. Dang VQ, Nguyen LK, Pham TD, He YTN, Vu KN, Phan MTN, et al. Pessary Compared With Vaginal Progesterone for the Prevention of Preterm Birth in Women With Twin Pregnancies and Cervical Length Less Than 38 mm: A Randomized Controlled Trial. Obstet Gynecol. 2019 Mar;133(3):459-467. doi: 10.1097/AOG.0000000000003136. PMID: 30741812.