Study/year
Country
Cervical length cutoff
GA at intervention
Design intervention x comparison
Primary outcome
Total sample (n= 4461)
Intervention sample size
Comparison sample size
Critical Appraisal (Rob2)
Liem 201342 The Netherlands <38mm* 16-22 Pes X NoI Composite neonatal adverse outcomes 133 78 55 Low risk
Nicolaides 201643 United Kingdom ≤25mm* 20-24 Pes X NoI sPTB<34 214 106 108 Low risk
Goya 201644 Spain ≤25mm 18-22 Pes X NoI sPTB<34 134 68 66 Low risk
Berghella 201745 United States ≤30mm 18-27 Pes X NoI PTB<34 46 23 23 Low risk
Dang 201947 Vietnam <38mm 16-22 Pes X Progv PTB<34 297 149 148 Low risk
P5 trial 20218 Brazil ≤30mm 18-22 PP X Progv200 Composite neonatal adverse outcomes 71 43 28 Low risk
STOPPIT-2 202146 Belgium, United Kingdom ≤35mm 18-20 Pes X NoI PTB<34 503 250 253 Low risk
PESSARONE 20229 France <35mm 16-24 Pes X NoI Composite neonatal adverse outcomes 310 155 155 Risk
Fonseca 200730 United Kingdom ≤15mm 20-25 Progv 200 X NoI sPTB<34 24 11 13 Low risk
Briery 200937 United States <40mm 20-30 ProgIM 250 X NoI PTB<35 30 16 14 Low risk
SSTARS 201038 United States <40mm 16-20w3d ProgIM 250 X NoI PTB or fetal death <35 565 235 330 Low risk
PREDICT 201131 Austria/Denmark/ United Kingdom <40mm 18-24 Progv200 X NoI PTB<34 675 334 341 Low risk
Combs 201139 United States <40mm 15-23 ProgIM 250 X NoI Composite neonatal adverse outcomes 238 160 78 Low risk
AMPHIA 201140 The Netherlands <35mm* 16-20 ProgIM 250 X NoI Composite neonatal adverse outcomes 61 37 24 Low risk
Aboulghar 201232 Egypt <40mm 18-24 Progv400 X NoI PTB<37 and <34 91 49 42 Risk
Wood 201233 Canada <40mm 16-21 Progv90g X NoI GA at birth 84 42 42 Low risk
Serra 201234 Spain <40mm 20w Progv200/400 X NoI PTB<37 289 194 95 Low risk
PHENIX 201341 France <25mm 20-31w6d ProgIM1000C Time from randomization to delivery 161 82 79 Low risk
Brizot 201535 Brazil <40mm 18-21 Progv200NoI Difference in mean GA at birth 380 189 191 Low risk
Rehal 202136 Belgium/ Bulgaria/ France/ Italy/ Spain/ United Kingdom <30mm* 11-14 Progv600NoI sPTB<34 155 85 70 Low risk