METHODS

Because of the ongoing TRD he was followed only with General health questionnaire (GHQ), Thyroid symptom questionnaire (TSQ), Beck Depression inventory scores (BDI-II) (6-8) and measurements of thyroid functions. Genotyping was performed per Allelic Discrimination protocol from real-time PCR machine (Applied Biosciences) using Taqman reagents and rs225014 SNP primer (9,10). Statistical analysis was performed by analysis of variance (ANOVA) and post-hoc analysis by Tukey test.