Biomarkers
We assessed several biomarkers that have been proposed to be associated
with CSU severity, such as CRP, D-dimer, basophil and eosinophil counts
and total IgE. In CSU-AE patients, we observed a significant inverse
correlation between UAS7 and eosinophil count (Spearman’s rho= -0.3086,
p=0.0392), while the other 4 parameters did not reach statistical
significance, although a trend was observed for some of them (Figure
2A). For CSU-AE, no significant correlation was observed between AAS7
and any biomarker (Figure 2B), while in CHA, AAS7 showed a significant
inverse correlation with D-dimer (Spearman’s rho= -0.3007, p=0.0243),
with no correlations observed with the rest of the biomarkers studied
(Figure 2C).
We also assessed the QoL score correlations with the selected
biomarkers. For CU-Q2oL, moderately significant
correlations were obtained for D-dimer (Spearman’s rho= 0.4479,
p=0.0005) and eosinophil counts (Spearman’s rho= -0.3780, p=0.0034). In
the case of CSU-AE, AE-QoL significantly correlated with the same
biomarkers as CU-Q2oL, namely, D-dimer (Spearman’s rho= 0.4636,
p=0.0003) and eosinophil counts (Spearman’s rho= -0.2867, p=0.0243). In
CHA, AE-QoL did not present any significant correlations.