Biomarkers
We assessed several biomarkers that have been proposed to be associated with CSU severity, such as CRP, D-dimer, basophil and eosinophil counts and total IgE. In CSU-AE patients, we observed a significant inverse correlation between UAS7 and eosinophil count (Spearman’s rho= -0.3086, p=0.0392), while the other 4 parameters did not reach statistical significance, although a trend was observed for some of them (Figure 2A). For CSU-AE, no significant correlation was observed between AAS7 and any biomarker (Figure 2B), while in CHA, AAS7 showed a significant inverse correlation with D-dimer (Spearman’s rho= -0.3007, p=0.0243), with no correlations observed with the rest of the biomarkers studied (Figure 2C).
We also assessed the QoL score correlations with the selected biomarkers. For CU-Q2oL, moderately significant correlations were obtained for D-dimer (Spearman’s rho= 0.4479, p=0.0005) and eosinophil counts (Spearman’s rho= -0.3780, p=0.0034). In the case of CSU-AE, AE-QoL significantly correlated with the same biomarkers as CU-Q2oL, namely, D-dimer (Spearman’s rho= 0.4636, p=0.0003) and eosinophil counts (Spearman’s rho= -0.2867, p=0.0243). In CHA, AE-QoL did not present any significant correlations.