Protective and risk factors for the development of atopic diseases: univariable analysis
In the univariable analysis, early daycare attendance between the ages of 5.5 and 8 years resulted in a significant reduction in the risk of developing asthma. Meanwhile, significant risks of developing asthma were noted for those infants who had a history of hospitalization owing to cold/bronchitis/bronchiolitis/pneumonia, preterm birth, and overweight gain (Table 1 and Tables S2–6). Children with rhinitis/conjunctivitis had inverse associations with early daycare attendance and older siblings while having a positive association with overweight gain. Children with atopic dermatitis had a higher frequency of early daycare, older siblings, and history of hospitalization owing to cold/bronchitis/bronchiolitis/pneumonia than those without atopic dermatitis. The results for the confounding factors are shown in Table 1 and Tables S2–6.