3. Results
3.1 General
characteristics of included studies
In total, 300 articles were
retrieved from PubMed following search strategy which were then screened
for selection of interested studies. Following exclusion criteria, 195
articles were removed, and the rest 106 full-texts articles were
assessed in depth following eligibility criteria. Finally, 42 articles
were included in this meta-analysis for assessing the associations ofUGT1A1*6/*28 or ABCC2 c.3972C>T with
irinotecan induced severe toxicities
[12,14,21,22-24,26-31,34,35,47-74]. The complete selection process
of articles following PRISMA guidelines is shown in Figure 1.
General characteristics of included articles e.g. author name, year of
publication, where the study was undertaken, design of study, genotyping
method, chemotherapy regimen, dose and schedule of irinotecan, toxicity
assessed etc. is shown in Table 1.