Author
Country
Study design Type of Cancer
No. of patients
Regimen
IRI dose (mg/m2)/schedule
Toxicity assessment
Genotyping method
Hirasawa A., et al. 2013 Japan Retrospective Gynecologic cancer 53 Irinotecan + Cisplatin or Irinotecan alone 60/(days 1, 8 and 15 every 4 weeks) or 100/(days 1, 8 and 15 every 4 weeks) Neutropenia, Diarrhea Invader UGT1A1 Molecular Assay kit
Ando K., et al. 2017 Japan Prospective Colorectal cancer 35 XELIRI 200/biweekly Neutropenia, Diarrhea N/A
Atasilp C., et al. 2015 Thailand Retrospective Colorectal cancer 44 FOLFIRI or FOLFIRI + cetuximab or FOLFIRI + bevacizumab or Modified FOLFIRI or Single irinotecan or Irinotecan + cetuximab/capecitabine 180/biweekly, 100/day 1 Neutropenia Pyrosequencing
Atasilp C., et al. 2020 Thailand Retrospective and Prospective Colorectal cancer 66 FOLFIRI or FOLFIRI + Cetuximab or FOLFIRI + Bevacizumab or Modified FOLFIRI or Single irinotecan or Irinotecan + Cetuximab or Irinotecan + capecitabine 180/biweekly or 180/every 3 weeks or 100/(day 1) Neutropenia Pyrosequencing, Real-time PCR
Bai Y., et al. 2017 China Retrospective Lung cancer, Colorectal cancer, E sophageal cancer 81 Single irinotecan or irinotecan + cisplatin or irinotecan + bevacizumab or irinotecan + cisplatin + bevacizumab or FOLFIRI or FOLFIRI + bevacizumab/cetuximb 60 (days 1, 8 and 15 for every 4 weeks) or 130 (day 1 for every 3 weeks) or 180/biweekly or 180 (day 1 for every 3 weeks) or 150/biweekly Neutropenia, Diarrhea DFMH using fluorescent probes
Bandyopadhyay A et al. 2021 India observational cohort Small cell lung cancer (SCLC) cell lung cancer 213 Irinotecan + cisplatin 100 (day 1 of a 3-week cycle) or 65(days 1 and 8 of a 3-week cycle) Neutropenia, Diarrhea polymerase chain reaction (PCR)– restriction fragment length polymorphism (RFLP)
Chen Yang., et al. 2015 China Retrospective Pancreatic cancer 48 FOLFIRI 180/biweekly Neutropenia Direct sequencing
Choi YH., et al. 2012 Korea Retrospective Colorectal cancer 29 CPT-11 + S-1 225/every 3 weeks Neutropenia, Diarrhea Direct sequencing
Chun-Yu Liu., et al. 2007 China Retrospective Colorectal cancer 128 FOLFIRI 180/biweekly Neutropenia, Diarrhea Direct sequencing
Deng B., et al. 2017 China Retrospective Malignant tumor 115 FOLFIRI 180/biweekly Neutropenia, Diarrhea Direct sequencing
Gao J., et al. 2013 China Retrospective Gastric cancer, Esophageal cancer 133 Irinotecan + cisplatin or FOLFIRI or single irinotecan or irinotecan + cetuximab 180 mg/m2 Neutropenia Direct sequencing
Gao J., et al. 2013 China Retrospective Colorectal cancer 276 FOLFIRI or single irinotecan or irinotecan + capecitabine 180 mg/m2 Neutropenia, Diarrhea Direct sequencing
Han JY., et al. 2007 Korea Prospective Non-Small Cell Lung Cancer 107 Single irinotecan or irinotecan + cisplatin 65 or 80/every 3 weeks Neutropenia and Diarrhea Sequencing
Han JY., et al. 2009 Korea Prospective Non-Small Cell Lung Cancer 107 Single irinotecan or irinotecan + cisplatin 65 or 80/every 3 weeks Neutropenia and Diarrhea Sequencing
Hironobu Minami., et al. 2006 Japan Retrospective Lung, Colon, Stomach and others 55 Single irinotecan 100/weekly Neutropenia Pyrosequencing
62 Irinotecan + Cisplatin 150/biweekly
103 IROX 200/every 3 weeks
Horikawa N., et al. 2015 Japan Retrospective Cervical cancer 23 CPT-11 + Nedaplatin (NDP) every 3 weeks 60 (day 1 and 8) Neutropenia, Diarrhea Direct sequencing
Kimura K., et al. 2018 Japan Retrospective Rectal cancer 46 Irinotecan-based regimen 80/day S-1 (days 1-5, 8-12, 22-26, and 29-33), 60 (days 1, 8, 22, and 29), and 45 Gy radiation (1.8 Gy/day, 5 daysper week for 5 weeks) Neutropenia, Diarrhea Invader assay
Liu D., et al. 2017 China Retrospective Colorectal cancer 661 Single irinotecan or irinotecan + target treatment or irinotecan + fluorouracil (5-Fu, Capecitabine, S-1 or tegafur) or FOLFOXIRI 180 mg/m2 or 150 mg/m2 Neutropenia, Diarrhea Direct sequencing
Masahide Onoue., et al. 2009 Japan Prospective Lung, Gastric, Colorectal and Others 133 Single irinotecan or Irinotecan + Platinum or Irinotecan + other anticancer agents or FOLFIRI <100 or 101-150 or 151-200 or >200/weekly or biweekly or every 3 or 4 weeks Neutropenia Direct sequencing
Matsuoka et al. 2020 Japan Retrospective Cervical cancer 51 Irinotecan + NDP 60/(days 1 and 8) or 60/(days 1 and 15) Neutropenia, Diarrhea Direct sequencing
Minmin Li., et al. 2014 China Retrospective Colorectal cancer 167 FOLFIRI or Irinotecan + Cetuximab/Bevacizumab or Irinotecan + Raltitrexed or Irinotecan + Capecitabine 180/biweekly or 180/every 3 weeks Neutropenia, Diarrhea Pyrosequencing
Moriya, H. et al. 2014 Japan Retrospective Gynecological cancer 44 Irinotecan + cisplatin or Irinotecan + mitomycin C 40-60/(days 1, 8 and 15) or 70-150/(days 1 and 15 or on days 1, 8 and 15) Neutropenia Direct sequencing
Nakamura Y., et al. 2011 Japan Randomized phase II trial Non-small Cell Lung Cancer 77 Irinotecan + paclitaxel or irinotecan + gemcitabine 50 (days 1, 8, and 15 for every 4 weeks) or 100 (days 1 and 8 for every 3 weeks) Neutropenia Direct sequencing
Okuyama Y., et al. 2011 Japan Prospective Colorectal cancer 39 FOLFIRI 150 mg/m2 or 100 mg/m2 Neutropenia polymerase chain reaction-restriction fragment length polymorphism
Park SR., et al. 2010 Korea Retrospective Gastric cancer 44 Irinotecan + oxaliplatin 150/every 3 weeks Neutropenia Direct sequencing
Peng H., et al. 2017 China Retrospective Gastrointestinal cancer, lung cancer 106 FOLFIRI or Single irinotecan or irinotecan + cisplatin or irinotecan + capecitabine 180 mg/m2 or 90 mg/m2 Neutropenia, Diarrhea Direct sequencing
Satoh T., et al. 2011 Japan Prospective Gastrointestinal cancer 73 Single irinotecan 150mg⁄m2 or 100 mg⁄m2 or 75 mg⁄m2 Neutropenia, Diarrhea Invader UGT1A1 Molecular Assay kit
Shi Y., et al. 2015 China Retrospective Small cell lung cancer 29 Irinotecan + cisplatin 65 mg/m2 Diarrhea Direct sequencing
Shaojun Chen., et al. 2020 China Retrospective Colorectal cancer 86 FOLFIRI 180/biweekly Neutropenia, Diarrhea Pyrosequencing
Sunakawa Y., et al. 2010 Japan Retrospective Colorectal cancer 42 FOLFIRI 180/biweekly Neutropenia, Diarrhea Direct sequencing
Takahara N., et al. 2013 Japan Prospective Pancreatic cancer 44 Single irinotecan 100 (days 1, 8 and 15 for every 4 weeks) Neutropenia Direct sequencing
Takano M., et al. 2009 Japan Prospective Gynecologic cancer 30 Irinotecan + cispatin 60 (day 1, 8,15 for every 4 weeks) Neutropenia, Diarrhea Invader UGT1A1 Molecular Assay
T. Yamaguchi et al. 2019 Japan Retrospective Gastric cancer 74 Irinotecan-based regimen 150/biweekly Neutropenia, Diarrhea The Invader® UGT1A1 Molecular Assay kit
Wang Y et al. 2012 China Retrospective Colorectal cancer 130 FOLFIRI or IFL 180/biweekly or 125/every 6 weeks Neutropenia, Diarrhea Direct sequencing
WANG et al. 2017 China Retrospective Lung, Colon, Rectum, Esophagus, Stomach and others 206 Irinotecan + antitumor platinum drugs or Irinotecan + 5-Fluorouracil or Irinotecan + Capecitabine or Single irinotecan 300-350/every 3 weeks or 250/every 3 weeks or 180/biweekly or 180/every 3 weeks Neutropenia, Diarrhea Direct sequencing
Xiao XG., et al. 2015 China Retrospective Extensive-stage small-cell lung cancer (E-SCLC) 67 CPT-11 + Appropriate platinum drug (cisplatin, carboplatin, or lobaplatin) 60 (day 1, 8,15 for every 4 weeks) or 85/every 3 weeks Neutropenia, Diarrhea Pyrosequencing
Xu, C. et al. 2016 China Retrospective Colorectal cancer 183 FOLFIRI or Irinotecan + Capecitabine 150/biweekly or 150/every 3 weeks Neutropenia, Diarrhea Direct sequencing
Xu Ma., et al. 2020 China Retrospective Pulmonary neuroendocrine tumours (PNTs) 68 Single irinotecan or irinotecan + cisplatin 60 (days 1, 8 and 15 for every 4 weeks) Neutropenia, Diarrhea quantitative fluorescent polymerase chain reaction
Xu Q, Ding YY., et al. 2015 China Retrospective Ovarian cancer 89 Irinotecan + cisplatin 60 (days 1 and 8 for every 3 weeks) Neutropenia, Diarrhea Pyrosequencing
Yamamoto N., et al. 2009 Japan Prospective Non–Small Cell Lung Cancer 36 Single CPT-11 100 (days 1 and 8 for every 3 weeks) Neutropenia Direct sequencing
Yan-Yan Lu., et al. 2014 China Retrospective Lung and Gastrointestinal cancer 89 Irinotecan + Cispatin, Nedaplatin, Carboplatin or Lobaplatin; modified FOLFIRI; Irinotecan + Platinum, Fluorouracil, Pemetrexed or Raltitrexed 100-175/biweekly or 100-175/every 3 weeks Neutropenia, Diarrhea Direct sequencing
Yun F., et al. 2014 China Retrospective Small cell lung cancer 31 Single irinotecan 80 (days 1 and 8 for every 3 weeks) Neutropenia, Diarrhea Direct sequencing