2. Methods
Search strategy
Literature search was carried out in PubMed from the inception to the
date up to May 22, 2021 following Preferred Reporting Items for
Systematic Reviews and Meta-Analyses (PRISMA) guidelines as described
elsewhere [41]. Five keywords i.e. “UGT1A1”, “ABCC2”
“Polymorphisms”, “Irinotecan” and “Toxicity” was used to search
eligible studies in PubMed. Furthermore, relevant references of
retrieved articles were also searched and reviewed for inclusion of
eligble studies.