Acknowledgements
This study was supported by grants from the Changzhou Sci&Tech Program (Grant No.CZQM2020011; CZQM2020079), Natural Science Foundation of Xinjiang Uygur Autonomous Region (2021D01F64), the National Natural Science Foundation of China (No. 81700500), the Applied Basic Research Programs of Science, Technology Department of Changzhou city (CJ20160031; CJ20190095), the Research Project of Jiangsu Province Commission of Health and Family Planning (No. H201547), the Major Scientific and Technological Project of Changzhou City Commission of Health and Family Planning (No. ZD201612) and the Scientific and Technological Project of NanJing medical University (No. 2017NJMU042).