Introduction
The Coronavirus disease 2019 (COVID-19) pandemic has revealed several
strange features of a viral infection. At the beginning of the pandemic,
it had been believed that COVID-19 is predominantly a respiratory
disease with occasional gastrointestinal involvement. Nevertheless, the
vast range of neurological, cardiovascular, dermatological and metabolic
complications occurring during the pandemic were later discovered to be
attributable to the virus[1-3]. Severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has led to many serious cardiac consequences,
including myocardial infarction in individuals with no cardiovascular
risk factors, which has subsequently been demonstrated to be the result
of this viral infection. Later, the introduction of SARS-CoV-2 vaccines
further complicated the condition. Despite being an essential health
issue, vaccines are sometimes followed by adverse events (AEs). Some
vaccine-associated AEs, like thromboembolic events, are
life-threatening, while others are only bothersome without risk of
death[4-7]. Postural orthostatic tachycardia syndrome (POTS) has
been among the most annoying, albeit nonlethal cardiovascular
complications, reported with SARS-CoV-2 infection and vaccination. Here,
we have comprehensively reviewed every aspect of the relationship
between POTS and COVID-19.