Introduction
The Coronavirus disease 2019 (COVID-19) pandemic has revealed several strange features of a viral infection. At the beginning of the pandemic, it had been believed that COVID-19 is predominantly a respiratory disease with occasional gastrointestinal involvement. Nevertheless, the vast range of neurological, cardiovascular, dermatological and metabolic complications occurring during the pandemic were later discovered to be attributable to the virus[1-3]. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to many serious cardiac consequences, including myocardial infarction in individuals with no cardiovascular risk factors, which has subsequently been demonstrated to be the result of this viral infection. Later, the introduction of SARS-CoV-2 vaccines further complicated the condition. Despite being an essential health issue, vaccines are sometimes followed by adverse events (AEs). Some vaccine-associated AEs, like thromboembolic events, are life-threatening, while others are only bothersome without risk of death[4-7]. Postural orthostatic tachycardia syndrome (POTS) has been among the most annoying, albeit nonlethal cardiovascular complications, reported with SARS-CoV-2 infection and vaccination. Here, we have comprehensively reviewed every aspect of the relationship between POTS and COVID-19.