Neonatal infection
The pooled data on severe neonatal infection included 9 studies with 22368 neonates. This was divided into 7569 neonates born to women with CID, 3554 neonates born to women requiring biologics treatment during pregnancy and 4015 disease matched controls (Table 1).
The proportion of severe neonatal infections requiring hospitalisations in the treated group was 5% (95% CI 0.03 to 0.07), the proportion in the disease matched group was 5% (0.02 to 0.07) and the disease free was 2% (0.02 to 0.02) (Figure S6). No differences were observed in proportions between disease matched compared with disease treated women (p=0.970), nor in disease free compared with disease treated women comparison (p=0.225; Table S1).  Subgroup analysis by disease diagnosis revealed no statistical difference between groups (results not shown).