Methods
This review was performed according to an a-priori -designed
protocol recommended for systematic reviews and
meta-analysis.13 Maternal and fetal systematic review
protocols were prospectively registered on PROSPERO CRD4201707072 and
CRD42020185926. The systematic review was based on the following PICO
requirements; Population: Pregnant women with a diagnosis of CID.
Intervention/Exposure: Treatment with Biologic medication. Comparison:
Pregnant women with a diagnosis of CID without treatment with biologics
and a CID free population. Outcomes: fetal outcomes included congenital
malformations, preterm delivery, severe neonatal infection, low birth
weight and small for gestational age. Maternal outcomes included severe
maternal infection, miscarriage and pre-eclampsia.