Study Inclusion and exclusion criteria
English language cohort, case-control, cross-sectional studies and case
series with a minimum n=30 were eligible for inclusion. Studies must
have been peer-reviewed and contain original data. A diagnosis of a CID
requiring treatment with biologics had to be described for women treated
during pregnancy/or the three months prior to pregnancy (as early
cessation of these medications is common).
Ineligible studies were those who did not specify maternal underlying
medical condition or a condition that was not a chronic inflammatory
disease e.g.: neoplasia. Studies that were not published in English,
those that did not address maternal or fetal outcomes, non-peer reviewed
studies, commentaries, reviews, and conference abstracts were excluded.