Neonatal infection
The pooled data on severe neonatal infection included 9 studies with
22368 neonates. This was divided into 7569 neonates born to women with
CID, 3554 neonates born to women requiring biologics treatment during
pregnancy and 4015 disease matched controls (Table 1).
The proportion of severe neonatal infections requiring hospitalisations
in the treated group was 5% (95% CI 0.03 to 0.07), the proportion in
the disease matched group was 5% (0.02 to 0.07) and the disease free
was 2% (0.02 to 0.02) (Figure S6). No differences were observed in
proportions between disease matched compared with disease treated women
(p=0.970), nor in disease free compared with disease treated women
comparison (p=0.225; Table S1). Subgroup analysis by disease diagnosis
revealed no statistical difference between groups (results not shown).