2.2 Annotation of images
All selected images of vocal cord leukoplakia were independently
annotated by 2 senior expert endoscopists with at least 10 years of
laryngoscopy experience; they did not participate in manipulating the
laryngoscope that took the targeted images, but were not blinded to
laryngoscopic findings and pathology. The boundaries of lesions in the
image were annotated with the LabelMe application
(https://github.com/wkentaro/labelme ) and used to represent the
actual lesion area within the image.