Diagnostic performance of prediction protocols for EP in PUL
A summary of the data reported in the twenty-nine studies and paired forest plots of sensitivity and specificity with corresponding 95% confidence intervals is presented in table S2. The summary of sensitivity and specificity of each study for the high-risk outcome is represented in Table 1. Figure 3 shows the summary receiver operating characteristic(SROC) curves for the protocol performances of M1, single hCG cut-offs, progesterone cut-offs, M4, M6 and hCG ratio respectively. As summarized in figure 3, M1 had an AUC of 0.907, the progesterone cut-offs an AUC of 0.725, the hCG ratio an AUC of 0.824, the hCG cut-offs an AUC of 0.586, the M4 an AUC of 0.871, and the M6 an AUC of 0.944 respectively. Pooled sensitivity, specificity, positive prediction value (PPV) and negative prediction value(NPV) data for the prediction protocols are also summarized in table 1.