Protocol Se (95% CI) Sp (95% CI) PPV (95% CI) NPV (95% CI) AUC
M1 0.78[0.66,0.86] 0.90[0.88,0.92] 0.42[0.34,0.51] 0.98[0.96,0.99] 0.907
Progesterone cut-off 0.80[0.76,0.83] 0.51[0.49,0.52] 0.16[0.15,0.17] 0.96[0.95,0.96] 0.725
M6 0.94[0.91,0.95] 0.78[0.77,0.79] 0.36[0.33,0.38] 0.99[0.99,0.99] 0.944
M4 0.78[0.76,0.81] 0.79[0.78,0.80] 0.34[0.32,0.36] 0.96[0.96,0.97] 0.871
P1 0.69[0.53,0.82] 0.73[0.68,0.78] 0.24[0.17,0.33] 0.95[0.91,0.97] /
hCG ratio 0.74[0.70,0.77] 0.81[0.80,0.83] 0.41[0.38,0.44] 0.95[0.94,0.95] 0.824
Progesterone+hCG 0.59[0.47,0.70] 0.74[0.70,0.77] 0.77[0.70,0.83] 0.93[0.90,0.95] /
hCG cut-off 0.52[0.47,0.57] 0.78[0.76,0.80] 0.32[0.28,0.35] 0.89[0.88,0.91] 0.586
Ultrasound+hCG ratio 0.82[0.64,0.92] 0.73[0.67,0.78] 0.26[0.18,0.36] 0.97[0.93,0.99] /
Ultrasound 0.78[0.63,0.89] 0.62[0.58,0.66] 0.14[0.10,0.19] 0.97[0.95,0.99] /
FFN 0.42[0.16,0.71] 0.65[0.46,0.80] 0.29[0.11,0.56] 0.76[0.56,0.89] /
Activin A 1.00[0.94,1.00] 1.00[0.98,1.00] 0.97[0.90,1.00] 1.00[0.99,1.00] /