Author (year) Study period Protocol Definition of EP in protocol
Nadim, B. 2020
2011.08-2018.09
P1
hCG ratio (48/0h) 0.8-0.99, and D7 hCG rises; hCG ratio (48/0h) >1 EP
M4 ≥5%
Bobdiwala, S. 2020 2015.01-2017.01 M6 Step 1 progesterone>2nmol/L and Step 2 M6 model≥5%
Van Calster, B. 2016 2003.07-2013.12 M6 Step 1 progesterone>2nmol/L and Step 2 M6 model≥5%
M4 ≥5% EP
Progesterone cut-offs(10nmol/L) >10nmol/L high risk
Fistouris, J. 2016 2011.01.01-2013.12.31 M4 ≥5% EP high risk
hCG ratio hCG ratio (48/0h) changes between 0.87-1.66
Bobdiwala, S. 2016 2012.08-2013.12 M4 ≥5% EP high risk
Van Calster, B. 2013 2003.07-2011 M4 ≥5% EP high risk
Barnhart, K. T. 2010
2003.02.01-2007.09.30(US) 2003.07.18-2004.10.09(UK)
M4
≥5% EP high risk
Condous, G. 2007b 2002.03.04-2003.07.17 M4 ≥5% EP high risk
M5 combined clinical symptoms as predictive factors with M4
Bignardi, T. 2008 2001.06.25-2004.10.09 hCG ratio (hCG 48/0 h) hCG ratio (48/0h) changes between 0.87-1.66
Kirk, E. 2007 2005.02.21-2006.02.20 M4 ≥5% EP high risk
Kirk, E. 2006 2003.08.07-2004.12.18 M1 >0.21
Condous, G. 2005b 2001.6.25-2003.4.14 hCG cut-offs(1000) >1000 IU/L
hCGcut-offs(1500) >1500 IU/L
hCGcut-offs(2000) >2000 IU/L
Condous, G. 2005a 2001.6.25-2003.4.14 Progesterone&hCG cut-offs Progesterone 10-50nmol/l and hCG>25u/l
Condous, G. 2004 2001.06-2002.12 M1 >0.21
Guha, S. 2014 2005.02-2012.08 M4 ≥5%
Progesterone cut-offs(10nmol/l) >10nmol/L
hCG ratio(0.87-1.66) 0.87-1.66
Kaplan, B. C. 1996 1991.08-1992.09 hCG cut-offs(1000mIU/mL) ≤1000mIU/mL
Dart, R. G. 1999b 1991.08-1998.08 hCG ratio+Ultrasonography hCG ratio 0.5-1.66 and an empty uterus at ultrasound
Dart, R. G. 2002
1995.01-2000.08
Ultrasonography
Empty endometrial cavity with or without a thickened endometrium.
Dart, R. G. 1998 1991.08-1994.12 hCG cut-offs(1000mIU/mL) ≤1000mIU/mL
Day, A. 2009 2004.01-2006.12 Progesterone cut-offs >10nmol/L
Mol, B. W. 1998 1993.09-1996.04 hCG cut-offs >1000IU/L
hCG cut-offs >1500IU/L
hCG cut-offs >2000IU/L
Dart, R. G. 1999a 1991.08-1997.08 hCG cut-offs ≤1000mIU/mL
Condous, G. 2007a 2002.03-2003.07 M1 >0.21
Dart, R. G. 1996 1991.08-1994.12 hCG cut-off >3000
El Bishry, G. 2008
-
hCG+progesterone cut-offs
16≤P<80 and hCG>25 P>80 and hCG >1000
Nowacek GE. 1999 - FFN FFN>50ng/mL
Morse, C. B. 2012 2007.10-2009.06 hCG ratio 0.53~0.64-1.35
Florio P. 2007 2004.11-2005.09 Progesterone cut-offs 5.01 ng/ml
hCG cut-offs 658IU/L
Activin A 0.37ng/ml
Zee, J. 2014 2007-2009 hCG ratio <1.66