Conclusion
this systematic review and meta‐analysis summarized the current
outcome-predictive protocols for PUL. It suggests that M6 has
considerable accuracy in diagnosis of EP in PUL. However, there are few
studies of M6, and the negative impact of more complex prediction steps
on clinical work is unknown. Using a single biomarker or a single type
of biomarker, such as progesterone threshold method, has a higher
average production utility, which indicates that it is more
cost-effective.