Figure legends
Fig 1 A show the proportion of CD59-negative granulocytes and erythroid cells detected by flow cytometry; 1B shows FLAER detection in the peripheral blood of PNH patients by flow cytometry.
Fig 2 The trend of Hb, RET%, LDH and TBIL level changes in 0 to 8 weeks before and after chemotherapy. A1/A2 and B1/B2 show the average levels of Hb and reticulocyte percentages before and after chemotherapy from baseline (0 weeks) to 8 weeks after chemotherapy, respectively. Hb and RET% increased significantly from before chemotherapy to 8 weeks after chemotherapy. C1/C2 and D1/D2 show the average levels of LDH and TBIL before and after chemotherapy from baseline (0 weeks) to 8 weeks after chemotherapy, reflecting the degree of intravascular hemolysis. After chemotherapy, lactate dehydrogenase (LDH) levels in all PNH patients decreased to slightly higher than the upper limit of the normal range in 8 weeks, and the LDH level in 15 patients dropped to the normal range.
Fig 3 Survival rate in the cohort of PNH patients. The overall survival (OS, %) of all enrolled patients over 10 years is shown inA . There was no significant difference in the effects of age, Hb level and LDH elevation on survival (B, C, and D).