Conclusion
Hypertriglyceridemia can be associated with acquired and congenital lipodystrophies.Such cases present a unique challenge in managing elevated triglyceride levels. . One of the types of congenital lipodystrophy syndromes is Mandibular hypoplasia, Deafness, Progeroid Features Associated Lipodystrophy Syndrome (MDPL). This syndrome is caused by a mutation in the POLD 1 gene which can alter its proofreading activity. Loss of subcutaneous fat, small mandible resulting in lower teeth overcrowding, premature aging, sensorineural hearing loss, prominent eyes, and a beaked nose are often seen. Metabolic abnormalities like diabetes mellitus and hypertriglyceridemia are commonly observed key features.Identifying this mutation and thus diagnosing this syndrome as the cause of hypertriglyceridemiacanhelp in making appropriate lifestyledecisions. For certain genetic conditions, it can also allow for more regular check-ups for monitoring for thedevelopment of future symptoms that can be expected in those syndromes.