Conclusion
Hypertriglyceridemia can be associated with acquired and congenital
lipodystrophies.Such cases present a unique challenge in managing
elevated triglyceride levels. . One of the types of congenital
lipodystrophy syndromes is Mandibular hypoplasia, Deafness, Progeroid
Features Associated Lipodystrophy Syndrome (MDPL). This syndrome is
caused by a mutation in the POLD 1 gene which can alter its proofreading
activity. Loss of subcutaneous fat, small mandible resulting in lower
teeth overcrowding, premature aging, sensorineural hearing loss,
prominent eyes, and a beaked nose are often seen. Metabolic
abnormalities like diabetes mellitus and hypertriglyceridemia are
commonly observed key features.Identifying this mutation and thus
diagnosing this syndrome as the cause of hypertriglyceridemiacanhelp in
making appropriate lifestyledecisions. For certain genetic conditions,
it can also allow for more regular check-ups for monitoring for
thedevelopment of future symptoms that can be expected in those
syndromes.