Figure 2. Clustering heatmap representing the clinical
manifestation of genetically confirmed MPS patients.
Figure 3. MPS patients’ ethnicity and age demographics. A)
Number of MPS patients among different ethnicities of the Iranian
population and relative distribution of MPS types among them. B)
Distribution of MPS patients based on their age at diagnosis divided by
each MPS type.
Figure 4. Geographical distribution of pathogenic variants
associated with MPS IV. Total number of patients = 90. Geographical
distribution was determined based on the parental origin of the affected
individuals. Variants with a concentrated pattern of distribution in a
region are shown underneath.
Figure 5. Geographical distribution of pathogenic variants in
the Iranian cohort associated with MPS I. Total number of patients =
59. Geographical origin was determined based on the parental origin of
the affected individuals. Variants with a concentrated pattern of
distribution in a region are shown underneath.
Figure 6. Geographical distribution of pathogenic variants in
the Iranian cohort associated with MPS VI. Total number of patients =
59. Geographical distribution was determined based on the parental
origin of the affected individuals. Variants with a concentrated pattern
of distribution in a region are shown underneath.
Figure 7. Geographical distribution of pathogenic variants in
the Iranian cohort associated with MPS II and III. Total number of MPS
II patients = 18. Total number of MPS III patients = 33. Geographical
origin was determined based on the parental origin of the affected
individuals.