Figure 2. Luminescence intensity thermometry measurements of an
individual lanthanide doped nanoparticle. Representative spectra taken
at two temperatures. Copyright Springer Nature 2018.
Single molecule spectroscopy on nanoparticle-protein conjugate has not
been reported so far. However, conjugation of proteins with
nanoparticles has been proposed. For example, Figure 3 shows an image of
a space-filling modeling approach to study interactions between a
maltose-binding protein and a semiconductor quantum
dot,19 with surface sulfur atoms in teal and zinc
atoms in pink. The red shell shows the estimated outer radius of the
dihydrolipoic acid ligand. The side chain of Lys-370 is shown in blue.