Immunosuppression protocol after pediatric LT
TAC, CsA, corticosteroids, and mycophenolate mofetil (MMF) were the principal scheme of IS drugs. Steroids were given intravenously with a gradually decreasing dosage and then gradually reduced to oral glucocorticoid during the first week after LT. The initial dose of TAC was 0.1-0.15 mg∙kg-1∙d-1 and the target blood concentration was 8-12 ng/mL at the first month, 7-10 ng/mL between the 2nd and 6th month, 5-8 ng/ mL between the 7th and 12th month and maintained 5 ng/mL according to the liver function after 1 year. The dosage of TAC was modified based on liver function and serum concentration of TAC. Adding MMF or switching TAC to CsA would be considered if the serum concentration of TAC was low and the target concentration could not be reached after increasing the dose of TAC or severe side effects occurred.