RESULTS
In this clinical trial, 143 adult patients were randomly assigned to
undergo off-pump CABG surgery. The flow of the patients throughout the
trial is shown in Figure 2 and their baseline
characteristics are summarized in Table 1 .
The diagnosis of ischemic heart disease was the cause of hospitalization
of our population, mainly alongside relaxation and hypokinesia disorders
in ten patients (50%), contractility and wall akinesia in three
patients (15%) and akinesia in five patients (25%).
On average, 2,25 anastomosis per patient were performed. The internal
mammary artery was routinely used for the anterior descending artery
(LAD). 45 anastomoses were performed on the 20 patients included in the
study.
A comparison of narcotic consumption and comparisons between gasometric
and electrolytic parameters in both groups are mentioned in Tables
2 - 3.
We obtained the records of hemodynamic variables at the following times
during transoperative in both groups: t1 = baseline; t2 = sternotomy, t3
= time of coronary anastomosis, t4 = sternal closure. We analyzed the
results at different times, regarding the heart rate, we obtained during
the sternal closure (t4) p = 0,004 and during the coronary anastomosis
(t3), with a value of p = 0,002, in the DEX group. (Tables 3)
Regarding the difference in the MAP in both groups, we observed
hemodynamic stability in the DEX group mainly during the performance of
anastomosis; during sternotomy and the placement of sternal closure, no
differences were observed.