ABSTRACT
Objective : We aimed to compare the effectiveness of esmolol
(ESM) vs. dexmedetomidine (DEX) in the treatment of increased
hemodynamic response during coronary artery bypass.
Methods: Following the approval of the Local Committee Research
and Ethics Health Research, a controlled randomized clinical trial, in
patients undergoing elective coronary revascularization during off-pump
coronary artery bypass surgery, was performed under standardized general
anesthesia. Patients randomly received infusions of ESM 0,5 mg /kg or
DEX 0,5 µcg/kg/hr. Hemodynamic variables of study: heart rate and MAP
were analyzed at different times: t1) baseline, t2) sternotomy, t3) time
of coronary anastomosis and t4) sternal closure.
Results : In group DEX, a statistic significance was found in
the heart rate sternotomy (t2) p=0,004 and heart rate (t3= time of
coronary anastomosis) p=0,026 and MAP during (t3) p=0,002.
Conclusions: Although ESM and DEX attenuate hemodynamic
response during coronary artery bypass, in the DEX group, hemodynamic
stabilization was observed in heart rate and MAP during coronary artery
bypass.
Keywords : “Esmolol” [MeSH], “dexmedetomidine”
[MeSH], “cardiac surgery” [MeSH], “median sternotomy”
[MeSH] “Off-Pump Coronary Artery Bypass” [MeSH].