AD severity and risk of aeroallergen sensitization
Among children with an early-onset AD, the highest severity score for AD (SCORAD) measured between 0-1 year showed associations with development of aeroallergen sensitization measured by sIgE. Per 1-point increase in SCORAD, the OR for aeroallergen sensitization at 6 years was 1.08 [1.03; 1.14], p<0.01, and the OR for aeroallergen sensitization at 12 years was 1.08 [1.03; 1.13], p=<0.01. The GEE model was significant with a compiled OR for the two timepoints of 1.08 [1.03; 1.12], p<0.001. Contrary, among children with a late-onset AD, the highest SCORAD measured from 1-6 years showed no significant associations with later development of aeroallergen sensitization (Table 2 ). Early-onset AD severity imposed a higher risk for development of sIgE aeroallergen sensitization than late-onset severity (p-interaction=0.03).