Conclusion
Our study suggests that increasing severity of early-onset AD is
associated with the development of sensitization to aeroallergens and
allergic rhinitis in childhood. Our findings imply that a skin barrier
defect and/or skin inflammation from AD in infants may have important
programming effects on development of respiratory allergy later in
childhood. These findings call for a randomized controlled trial of
early oral exposure to aeroallergens to reduce the risk for developing
aeroallergen sensitization and allergic rhinitis in children, similar to
what has been shown for primary prevention of food allergies.