Conclusion
Our study suggests that increasing severity of early-onset AD is associated with the development of sensitization to aeroallergens and allergic rhinitis in childhood. Our findings imply that a skin barrier defect and/or skin inflammation from AD in infants may have important programming effects on development of respiratory allergy later in childhood. These findings call for a randomized controlled trial of early oral exposure to aeroallergens to reduce the risk for developing aeroallergen sensitization and allergic rhinitis in children, similar to what has been shown for primary prevention of food allergies.