Age at onset of AD and risk of sIgE aeroallergen sensitization
Aeroallergen sensitization measured by sIgE (≥ 0.35 kUA/L) at 6 years was present in 29/84 (35%) children with early-onset AD compared to 45/207 (22%) children without early-onset AD: OR=1.90 [1.08; 3.31], p=0.02. At 12 years, aeroallergen sensitization was present in 48/89 (54%) vs. 92/215 (43%): OR=1.56 [0.95; 2.58], p=0.08. The GEE model of early-onset AD showed a compiled significantly increased OR for developing aeroallergen sensitization at the two timepoints of 1.68 [1.08; 2.62], p=0.02 (Table 2 ).
In children with late-onset AD (1-6 years of age), aeroallergen sensitization at 6 years was diagnosed in 15/53 (28%) compared to 28/145 (19%) without late-onset AD: OR=1.65 [0.78; 3.38], p=0.18. At 12 years, aeroallergen sensitization was present in 26/49 (53%) vs. 54/136 (40%) : OR=1.72 [0.89; 3.33], p=0.11. The GEE model showed a compiled borderline-significant OR for the two timepoints of 1.65 [0.92; 2.94], p=0.08 (Table 2 ). Early-onset and late-onset AD imposed a similar risk of development of sIgE aeroallergen sensitization (p-interaction=0.93).