Allergic rhinitis
Allergic rhinitis was diagnosed at the COPSAC research unit at age 7 and
12 years based on a parental interview on history of symptoms. Allergic
rhinitis was defined
as
substantial and reoccurring sneezing, blocked, itchy or runny nose
severely affecting the wellbeing of the child in the past 12 months in
periods without accompanying common cold or flu, and with congruence
between symptoms, relevant exposure and aeroallergen sensitization
(positive sIgE and/or skin prick test)19–22.
Filaggrin mutationGenotyping for common loss-of-function mutations in FLG , R501X,
2282del4, R2447X and S3247X was performed as previously
described.2 A FLG mutation carrier was defined
as having at least one gene mutation.