2.2.1 Clinical presentation
A 2-day-old Percheron colt was presented for lethargy and urine dripping
from the umbilicus. The colt was lethargic and febrile
(39.20C; reference range:
37.5-38.60C) on presentation with a firm and
subjectively enlarged umbilicus. Ultrasonographic evaluation revealed
moderate enlargement of the umbilical vein extending cranially and mild
umbilical artery enlargement. IgG stall side snap test revealed partial
failure of passive transfer (400 mg/dL; reference range:
>800 mg/dL). Initial therapy included intravenous plasma
transfusion 1L, antibiotics (ceftiofur sodium 5 mg/kg, intravenously, q
12 hours and amikacin sulfate 25 mg/kg, intravenously, q 24 hours) and
flunixin meglumine (1.1 mg/kg, intravenously, q 24 hours).
Forty-eight hours after presentation, hematology revealed leukopenia
(2,140 cells/uL; reference range: 5-12 x103/uL)
characterized by profound neutropenia (663 cells/uL; reference range:
2.18-6.96 x103/uL) and hyperfibrinogenemia (700 mg/dL;
reference range: 300-500 mg/dL).