Endothelial cell MR deficient models
Blocking specifically MR in endothelial cells protected against aldosterone-impaired endothelial function only in aorta (not in resistance arteries) (Rickard et al., 2014). Moreover, endothelial cell MR-knockout mice presented reduced cardiac fibrosis and inflammation in the absence of blood pressure reduction when treated with DOCA/salt (Rickard et al., 2014). Endothelial MR deletion improved capillary density in DOCA-treated mice (Lother et al., 2018b). Selective MR deletion in endothelial cells protected from the decline in systolic function in response to thoracic aortic constriction (Salvador et al., 2017). NDF failed to increase mitral valve area, thickness, or proteoglycan content in mice specifically lacking endothelial MR expression (Ibarrola et al., 2020b). MR deletion in endothelial cells decreased the endothelial dysfunction in obese female mice (Davel et al., 2018). Selective endothelial cells MR deficient mice were protected against obesity-induced endothelial dysfunction (Schäfer et al., 2013). Endothelial cell-specific MR ablation also improved hypoxia-induced pulmonary vascular remodeling to a similar extent as did eplerenone treatment (Kowalski et al., 2021).