Fibroblast MR deletion
Against the common believe that MR activation in fibroblasts essentially
contributes to LV remodeling, cell-specific fibroblast MR-null mice were
not protected against pressure overload-induced cardiac fibrosis and
dysfunction (Lother et al., 2011). Also in an animal model of pulmonary
hypertension, fibroblast-specific MR knockout was not protective against
pulmonary vascular remodeling (Kowalski et al., 2021).