Animal models
To further evidence the role of MR activation and the beneficial effects of MR blockade in CV diseases in more detail, researchers performed classical experiments employing MRA in pathological animal models (Riehle and Bauersachs, 2019), and also created dedicated mice with cell-specific MR deletion or overexpression. The study of these models has allowed analyzing the cellular and molecular mechanisms underlying the beneficial effects of MR blockade and has led to the identification of new potential pharmacological targets in the aldosterone/MR system.