5 | CONCLUSIONS
Roundworms has undergone significant differentiation and host specificity in the process of accompanying host evolution. This can be clearly seen in the evidence in morphology and molecular biology. The roundworm genome provides the possibility to study the details of gene selection or loss in the process of roundworm differentiation. It is also the case that some of the genes we have identified have potentially allowed new avenues for gene selection and intestinal environment adaption, for example, epidermal chitin synthesis, environmental information and essential amino acid metabolism. In addition, population genomics analysis and drug prediction provide insights for revealing the impact of deworming history on population genetic structure and prevention.