5 | CONCLUSIONS
Roundworms has undergone a remarkable evolutionary adaptation to specific hosts accompanying host evolution. The roundworm genome provides a possibility to study the details of gene selection or loss in the process of evolution and adaptation to the intestinal environment, including genes involved in epidermal chitin synthesis, environmental information, and essential amino acid metabolism. In addition, population genomics analysis and drug prediction provide insights revealing the impact of deworming history on population genetic structure and future development of novel anthelmintic drugs.