3.2.1. Gross anatomical examination of the explanted vagina and the implant contraction
All implants were well incorporated in the deeper vaginal tissue layers without any signs of encapsulation. We did not observe any exposure of P4HB scaffolds or fluid collection at 60- and 180-days post-implantation. Sheep implanted with PP mesh (n=6) developed vaginal synechiae (n=3). P4HB scaffolds were intact, without macroscopic deformation. Shrinkage (% area) of the implants after 60 days and 180 days were 52.2 ± 10.41 SD and 45.9 ± 7.95 SD, respectively. The shrinkage of the PP implants (29.6±7.8 SD and 46.7±14.2 SD) at 60 and 180 days post-implantation were reported as this previously (4).