3.2.1. Gross anatomical examination of the explanted
vagina and the implant contraction
All implants were well incorporated in the deeper vaginal tissue layers
without any signs of encapsulation. We did not observe any exposure of
P4HB scaffolds or fluid collection at 60- and 180-days
post-implantation. Sheep implanted with PP mesh (n=6) developed vaginal
synechiae (n=3). P4HB scaffolds were intact, without macroscopic
deformation. Shrinkage (% area) of the implants after 60 days and 180
days were 52.2 ± 10.41 SD and 45.9 ± 7.95 SD, respectively. The
shrinkage of the PP implants (29.6±7.8 SD and 46.7±14.2 SD) at 60 and
180 days post-implantation were reported as this previously (4).