Study objectives
The primary objective of this study was to elucidate the incidence of rhabdomyolysis following type A aortic dissection surgeries and to correlate it’s the severity with the patient outcome –primarily in terms of renal function. Other outcome measures included mechanical ventilation duration, length of ICU stay, duration of hospital stay, and mortality. We also proposed to formulate a risk scoring system based on preoperative and intraoperative variables to predict the development of RML after AAD surgery
Study definitions:
We followed the same definition for Rhabdomyolysis which we used in our previous study.
In cardiac surgery, a higher cut off value (2500 U/L) to diagnose RML is proposed to account for the release of CK from related myocardial injury1. Patients were divided into two groups based on this diagnostic cutoff; Group A with RML (CK value above 2500 U/L) & Group B without RML (CK below 2500 U/L). Acute kidney injury was defined using the KDIGO criteria AKI – KDIGO criteria define AKI as a 0.3 mg/dl (≥26.5 µmol/l) Serum Creatinine increase from baseline within 48 hours of surgery, a 1.5 times Serum Creatinine increase from baseline within 7 days of surgery17. The original KDIGO criteria also use urine output below 0.5 ml/kg/hour for 6 hours to define AKI. Urine output criteria were not used to define AKI in our study due to data collection difficulties, as adopted from a similar study on the subject9.