Figure 9. Schematic diagram illustrating the protective effects of NF-κB inhibitor 270 on LPS-induced septic acute kidney injury and acute lung injury and the underlying mechanism.
LPS can induce NF-κB activation via IKK and JNK pathways, and then translocates from the cytoplasm to nucleus, which triggers the transcription of target genes. LPS can trigger oxidative stress evidencing by the increase of MDA. LPS can activate ER stress via up-regulating BiP and CHOP protein level. LPS can inhibit autophagy via accumulating LC3A and p62 protein. Oral treatment with 270 protected LPS induced AKI and ALI by suppressing IKK/ NF-κB and JNK signaling pathway improving inflammation, inhibiting oxidative stress and ER stress, and activating autophagy.