Key Results:
In vitro, we showed that 270 suppressed the inflammation response in
LPS-induced RAW 264.7 macrophages and bone marrow derived macrophages.
In vivo, we found that 270
ameliorated LPS-induced AKI and ALI,
as evidenced by improving various pathological changes, reducing the
expression of pro-inflammation genes, blocking the activation of NF-κB
and JNK pathways, attenuating the elevated myeloperoxidase (MPO)
activity and malondialdehyde (MDA) content, ameliorating the activated
ER stress, reversing the inhibition effect on autophagy in kidney and
lung tissues, and alleviating the enhanced plasma level of creatinine
(Crea), blood urea nitrogen (BUN) and pro-inflammation cytokines.