Abbreviations
ALI, acute lung injury; AKI, acute kidney injury; ARDS, acute respiratory distress syndrome (ARDS); BMDMs, bone marrow derived macrophages; BUN, blood urea nitrogen; CETSA, cellular thermal shift assay; CKD, chronic kidney disease; CMC-Na, sodium carboxymethylcellulose; COX-2, cyclooxygenase-2; Crea, creatinine; ER, endoplasmic reticulum; ESKD, end-stage kidney disease; GAPDH, glyceraldehydes-3-phosphate dehydrogenase; HE, haematoxylin and eosin; HG-DMEM, high-glucose Dulbecco’s modified eagle’s medium; IL-, interleukin; IκB-α, B-cells inhibitor alpha; IKK, IκB kinase; JNK, Jun-aminoterminal kinase; KIM1, kidney injury molecule 1; LC3A, Light Chain 3 A; LPS, lipopolysaccharide; MCP 1, monocyte chemoattractant protein; MDA, malondialdehyde; mM-CSF, mouse macrophage colony stimulating factor; MPO, myeloperoxidase; NF-κB, nuclear factor-kappa B; NGAL, neutrophil gelatinase-associated lipocalin; Nos2, inducible NO synthase; p62, Sequestosome 1; PTL, parthenolide; TNF-α, tumour necrosis factor α; Veh, the control group.