Figure 9. Schematic diagram illustrating the protective effects
of NF-κB inhibitor 270 on LPS-induced septic acute kidney injury and
acute lung injury and the underlying mechanism.
LPS can induce NF-κB activation via IKK and JNK pathways, and then
translocates from the cytoplasm to nucleus, which triggers the
transcription of target genes. LPS can trigger oxidative stress
evidencing by the increase of MDA. LPS can activate ER stress via
up-regulating BiP and CHOP protein level. LPS can inhibit autophagy via
accumulating LC3A and p62 protein. Oral treatment with 270 protected LPS
induced AKI and ALI by suppressing IKK/ NF-κB and JNK signaling pathway
improving inflammation, inhibiting oxidative stress and ER stress, and
activating autophagy.